Serum cytokine and anti-Fc gamma R autoantibody measurements in patients with systemic sclerosis.
DOI:
https://doi.org/10.2340/00015555762123Abstract
The serum IL-1 beta, IL-2, IL-4, IL-6, IL-8, TNF-alpha and soluble IL-2 receptor levels were measured, and the presence of anti-Fc gamma receptor (Fc gamma R) antibodies was investigated in the sera of 18 patients with systemic sclerosis (SSc). An increase of TNF-alpha was detected in 8 of the 18 cases. II-1 beta was elevated in all the 18 patients. Both IL-2 and IL-4 were elevated in 7 cases. The IL-6 level was elevated in 17 patients, while IL-8 was increased in all cases. The soluble IL-2 receptor level was elevated in 11 patients. Fc gamma R-specific antibodies were detected in the sera of 6 patients, and there was a significant association between anti-Fc gamma R antibody positivity and IL-4 elevation. The presence of anti-Fc gamma R antibodies may influence several cell functions and may contribute to the remarkable variability of cytokine levels in SSc.Downloads
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Published
1996-01-01
How to Cite
Szegedi, A., Czirják, L., Unkeless, J., & Boros, P. (1996). Serum cytokine and anti-Fc gamma R autoantibody measurements in patients with systemic sclerosis. Acta Dermato-Venereologica, 76(1), 21–23. https://doi.org/10.2340/00015555762123
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