Phototoxicity of non-steroidal anti-inflammatory drugs: in vitro studies with visible light.
DOI:
https://doi.org/10.2340/0001555576337340Abstract
Photosensitivity reactions due to non-steroidal anti-inflammatory drugs (NSAID) are well-known side-effects of these agents and are usually attributed to ultraviolet (UV) radiation. Eight NSAID (carprofen, diclofenac, ibuprofen, ketoprofen, naproxen, piroxicam, phenylbutazone, tiaprofenic acid) were assessed in a photohemolysis test for phototoxic effects in the visible light range. For the studies an experimental visible light lamp was used, emitting 5% UVA at most. To control for UVA-induced effects, additional samples were exposed to appropriate UVA doses from an UVA source and as well to the visible light lamp while being covered by a GG 400 or GG 420 filter. Photo-induced hemolysis was found after exposure to the visible light lamp with carprofen, ketoprofen, naproxen, piroxicam, phenylbutazone or tiaprofenic acidDownloads
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Published
1996-09-01
How to Cite
Becker, L., Eberlein-König, B., & Przybilla, B. (1996). Phototoxicity of non-steroidal anti-inflammatory drugs: in vitro studies with visible light. Acta Dermato-Venereologica, 76(5), 337–340. https://doi.org/10.2340/0001555576337340
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