E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis.

Authors

  • H L Rilo
  • P B Carroll
  • V Subbotin
  • N Johnson
  • D H Van Thiel
  • A W Thomson

DOI:

https://doi.org/10.2340/00015555743742

Abstract

A study of the histopathological abnormalities in a case of alopecia universalis was accompanied by immunohistochemical analysis of the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin (formerly known as endothelial leukocyte adhesion molecule-1) within the skin. ICAM-1 expression on follicular epithelium co-localized with intraepithelial mononuclear cells (MNC) positive for the interleukin-2 receptor alpha-chain (IL-2R) or HLA-DR. Aberrant expression of E-selectin was observed on dermal endothelium. Although restricted to one case, these new observations concerning the expression of E-selectin and IL-2R in alopecia universalis are consistent with the view that extravascular trafficking of MNC into follicular epithelium may play a key role in the pathogenesis of alopecia universalis and that use of agents that interfere with this process may be an effective therapeutic strategy.

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Published

1994-01-01

How to Cite

Rilo, H. L., Carroll, P. B., Subbotin, V., Johnson, N., Van Thiel, D. H., & Thomson, A. W. (1994). E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis. Acta Dermato-Venereologica, 74(1), 33–36. https://doi.org/10.2340/00015555743742

Issue

Vol. 74 No. 1 (1994)

Section

Articles

License

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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