Interaction between tachykinins and CGRP in human skin.
DOI:
https://doi.org/10.2340/0001555573259261Abstract
Substance P (SP), neurokinin A (NKA) and calcitonin gene/related peptide (CGRP) coexist in nerve fibres in the skin. CGRP causes erythema upon intracutaneous injection. The erythema is independent of axon reflexes and release of mast cell histamine. SP is known to produce a flare reaction that is dependent on axon reflexes and release of mast cell histamine. The flare reaction to NKA is known to depend predominantly on axon reflexes. The purpose of the present study was to investigate possible cooperation between SP and CGRP. SP was found to shorten the duration of the reddening induced by CGRP, injected concomitantly. NKA did not shorten the duration of the CGRP response. Local elimination of mast cells in the skin by treatment with compound 48/80 had the effect that SP lost its ability to shorten CGRP/evoked erythema. These observations support the suggestion that an SP/evoked release of proteolytic enzymes from mast cells could lead to accelerated degradation of CGRP.Downloads
Download data is not yet available.
Downloads
Published
1993-08-01
How to Cite
Wallengren, J., & Wang, Z. Y. (1993). Interaction between tachykinins and CGRP in human skin. Acta Dermato-Venereologica, 73(4), 259–261. https://doi.org/10.2340/0001555573259261
Issue
Section
Articles
License
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
