Initiation of the effects of acrivastine and cetirizine on histamine/induced wheals and itch in human skin.
DOI:
https://doi.org/10.2340/0001555573350351Abstract
The initiation of the antihistamine effect of a single dose of acrivastine (8 mg) or cetirizine (10 mg) on wheals and itch induced by histamine dihydrochloride (10 mg/ml) in the prick test was studied in a randomized cross/over design employing 20 healthy medical students. The prick test was performed before ingestion of the drug and after 15, 20, 25, 30, 60 and 90 min and 2, 3 and 4 h. Local symptoms (itching) were recorded on a visual analogue scale. The inhibitory effect of acrivastine on the histamine wheal was first noticed 20 min (p < 0.01) after ingestion of the drug and that of cetirizine after 60 min (p < 0.001). The maximum effect of cetirizine, at 4 h, was greater than that of acrivastine, at 3 h (p < 0.001). The suppression of itching was first noticed 25 min after ingestion with both drugs.Downloads
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Published
1993-10-01
How to Cite
Lahti, A., & Haapaniemi, T. (1993). Initiation of the effects of acrivastine and cetirizine on histamine/induced wheals and itch in human skin. Acta Dermato-Venereologica, 73(5), 350–351. https://doi.org/10.2340/0001555573350351
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