Drug-triggered pemphigus in a predisposed woman.
DOI:
https://doi.org/10.2340/00015555724849Abstract
A 31-year-old woman with three pemphigus-prone antigens in her HLA haplotype (B7, DR4, DQw7) developed the disease soon after taking a pyrazolone derivative, viz. feprazone. The pemphigus lesions persisted despite withdrawal of the drug and worsened appreciably when she used ceftriaxone (a new cephalosporin with three sulphur atoms) for a bout of acute pharyngitis. Thiol groups formed from the metabolic breakdown of ceftriaxone are thought to have promoted acantholysis via a biochemical route. Genetic predisposition alone ('the soil') may be essential, though not per se sufficient for outbreak of pemphigus the intervention of exogenous, heterogeneous factors ('the seed') often seems decisive in triggering full-blown disease.Downloads
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Published
1992-01-01
How to Cite
Ruocco, V., Gombos, F., & Lombardi, M. L. (1992). Drug-triggered pemphigus in a predisposed woman. Acta Dermato-Venereologica, 72(1), 48–49. https://doi.org/10.2340/00015555724849
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