Methotrexate hepatotoxicity in psoriatic patients submitted to long-term therapy.
DOI:
https://doi.org/10.2340/0001555572361364Abstract
Eighty-four patients with severe psoriasis who required methotrexate (MTX) therapy have been reviewed. A total of 134 liver biopsies were performed. The lack of correlation between alcohol intake and the use of potential hepatotoxic drugs with pretreatment liver biopsies is noted. A review of 30 patients who had liver biopsies performed before and after MTX treatment showed no statistically significant difference between the histological grades before and after treatment. Nor was there any absolute correlation between the cumulative MTX doses and the histological changes of follow-up biopsies. In this group of patients, 15 (50%) developed fibrosis, which was severe in 2 patients, after 3,431 mg MTX average dose. Cirrhosis was observed in 3 patients (10%) after 1,667 mg MTX average dose. Follow-up liver biopsies are recommended for patients treated with MTX.Downloads
Download data is not yet available.
Downloads
Published
1992-09-01
How to Cite
Themido, R., Loureiro, M., Pecegueiro, M., Brandão, M., & Campos, M. C. (1992). Methotrexate hepatotoxicity in psoriatic patients submitted to long-term therapy. Acta Dermato-Venereologica, 72(5), 361–364. https://doi.org/10.2340/0001555572361364
Issue
Section
Articles
License
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
