Effect of PUVA radiation on anaphylactic histamine release from rat dermal tissues.
DOI:
https://doi.org/10.2340/0001555571159162Abstract
We have devised a new in vitro model of type I cutaneous anaphylaxis. Male albino rats were sensitized with DNP-Ascaris. Abdominal skin was shaved, and thin, split-thickness slices of skin were cut with a dermatome. The dermis was excised and cut into 100 mg pieces. The dermal tissue was incubated with antigen in Tyrode's solution for 30 min at 37 degrees C. Antigen-induced histamine release from dermal tissue was measured fluorimetrically. Using this system, we measured histamine release from PUVA-irradiated and non-irradiated dermal tissues. A single PUVA irradiation inhibited type I cutaneous anaphylaxis, but did not affect spontaneous histamine release or total dermal histamine. Our model is considered to be useful for investigation of the mechanism of suppression of type I cutaneous anaphylaxis by PUVA.Downloads
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Published
1991-01-01
How to Cite
Tanii, T., Kono, T., Mizuno, N., Furukawa, M., Nagahama, K., Someda, Y., … Okada, T. (1991). Effect of PUVA radiation on anaphylactic histamine release from rat dermal tissues. Acta Dermato-Venereologica, 71(2), 159–162. https://doi.org/10.2340/0001555571159162
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