Interleukin-1 decreases the number of Ia+ epidermal dendritic cells but increases their expression of Ia antigen.
DOI:
https://doi.org/10.2340/0001555570391394Abstract
It is generally accepted that ETAF/IL-1 is produced in epidermis by both keratinocytes and Langerhans' cells. We have studied the density and morphology of Ia+ epidermal dendritic cells in mice after systemic or intracutaneous injection of recombinant IL-1 beta. We found that rIL-1 beta decreased the density of Ia+ dendritic cells in the time period 2-7 days after rIL-1 beta administration. However, the remaining dendritic cells were enlarged and more arborized with increased expression of Ia antigen 1-4 days after injection of rIL-1 beta. The implication of the results is that ETAF/IL-1 modulates the function of Langerhans' cells through autocrine and paracrine regulation.Downloads
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Published
1990-09-01
How to Cite
Lundqvist, E. N., & Bäck, O. (1990). Interleukin-1 decreases the number of Ia+ epidermal dendritic cells but increases their expression of Ia antigen. Acta Dermato-Venereologica, 70(5), 391–394. https://doi.org/10.2340/0001555570391394
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