The effect of clobetasol-17-propionate and crude coal tar on dithranol-induced inflammation. A clinical and biochemical study.
DOI:
https://doi.org/10.2340/0001555570434437Abstract
Clobetasol-17-propionate (CP) and crude coal tar (CT) have an anti-inflammatory potential. Both agents have been advocated to suppress irritation of the skin during dithranol treatment. The effect of CP and CT on dithranol-induced irritation was studied by the assessment of erythema and measurement of alkaline phosphatase (ALP) as a direct reflection of the metabolic activity of the endothelial cells. Dithranol was applied for 2 h in the relatively high concentration of 10%, which resulted in a marked inflammation of the skin in all volunteers. Neither CP nor CT influenced the erythema. In contrast, CP and CT had a synergistic effect on the dithranol-induced induction of ALP. In conclusion, the present study indicates that CP and CT are not indicated for the treatment of dithranol-induced irritation.Downloads
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Published
1990-09-01
How to Cite
van de Kerkhof, P. C., & Timmerman, M. G. (1990). The effect of clobetasol-17-propionate and crude coal tar on dithranol-induced inflammation. A clinical and biochemical study. Acta Dermato-Venereologica, 70(5), 434–437. https://doi.org/10.2340/0001555570434437
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