An approach to experimental scleroderma, using urinary glycosaminoglycans from patients with systemic scleroderma
DOI:
https://doi.org/10.2340/00015555597107Abstract
As a result of intraperitoneal injections in mice of crude glycosaminoglycans obtained from the urine of patients with systemic scleroderma, a fibrotic process similar to the intial changes of human scleroderma was frequently observed, especially in the skin and esophagus when the glycosaminoglycans contained a probable variant of heparan sulfate. Furthermore, the scleroderma-like change was also observed, to some extent, in the ultrastructure of collagen fibers and glycosaminoglycans of the skin.Downloads
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Published
1975-03-01
How to Cite
Ishikawa, H., Suzuki, S., Horiuchi, R., & Sato, H. (1975). An approach to experimental scleroderma, using urinary glycosaminoglycans from patients with systemic scleroderma. Acta Dermato-Venereologica, 55(2), 97–107. https://doi.org/10.2340/00015555597107
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