Attempts to induce sensitization in guinea pigs with nickel complexes
DOI:
https://doi.org/10.2340/000155555475480Abstract
A technique for the induction of sensitization in pigs with a nickel-alanine conjugate has been reported by other investigators. Similar results were observed in our experiments in mini-pigs. However, using the identical technique, we were unable to induce sensitization in guinea pigs with NiSO4, with nickel-alanine or other nickel-amino acid complexes, or with a complex of nickel with soluble guinea pig skin extract. These results indicate that nickel-amino acid complexes and nickel-guinea pig skin complex were not antigenic in guinea pigs with this technique. Hypotheses for the apparent failure to induce sensitization are proposed.Downloads
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Published
1975-11-01
How to Cite
Samitz, M., Katz, S., Scheiner, D., & Lewis, J. (1975). Attempts to induce sensitization in guinea pigs with nickel complexes. Acta Dermato-Venereologica, 55(6), 475–480. https://doi.org/10.2340/000155555475480
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