Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma: A Retrospective Study

Authors

  • Florian Herms AP-HP Department of Dermatology, Université de Paris, DMU ICARE, INSERM U976 HIPI, Team 1 Hôpital Saint-Louis, FR-75010 Paris, France
  • Barouyr Baroudjian
  • Julie Delyon
  • Pauline Laly
  • Pauline Tetu
  • Celeste Lebbe
  • Nicole Basset-Seguin

DOI:

https://doi.org/10.2340/actadv.v102.1995

Keywords:

basal cell carcinoma, sonidegib, hedgehog pathway inhibitor, locally advanced

Abstract

Sonidegib, a hedgehog pathway inhibitor, is indicated for treatment of locally advanced basal cell carcinoma, based on the results of the BOLT study. However, to date, no real-world study of sonidegib has been reported. An observational, retrospective, single-centre study (PaSoS study) was conducted. The primary objective was to evaluate the efficacy of sonidegib for treatment of locally advanced basal cell carcinoma in a real-world setting. Secondary objectives included modalities of use, tolerability, tumour evolution, and management after discontinuation. A total of 21 patients treated with sonidegib were included from March 2018 to January 2021. The median follow-up was 18.7 months and median exposure 7.0 months. Objective response (OR) rate was 81.0% (n = 17) including 6 (29%) patients with a complete response (CR). Disease control rate was 100%. First tumour response was rapid, with a median time of 2.3 months. Nine (43%) patients underwent surgery after sonidegib discontinuation, and no relapse was observed. All the patients experienced at least 1 adverse event (AE). Muscle spasms were the most frequent AE (n = 14; 67%), followed by dysgeusia (n = 8; 38%) and alopecia (n = 12; 57%). The efficacy and safety profile of sonidegib in this first-to-date real-life trial are consistent with prior results. Overall, real-world evidence corroborated sonidegib efficacy and tolerability as a first-line treatment for locally advanced basal cell carcinoma.

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Published

2022-06-21

How to Cite

Herms, F., Baroudjian, B., Delyon, J., Laly, P., Tetu, P., Lebbe, C., & Basset-Seguin, N. (2022). Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma: A Retrospective Study. Acta Dermato-Venereologica, 102, adv00740. https://doi.org/10.2340/actadv.v102.1995

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