Tofacitinib for Treatment of Alopecia Areata: Real-world Evidence and Factors Associated with Therapeutic Response

Authors

  • Manuel Sanchez-Diaz Dermatology Unit, Hospital Universitario Virgen de las Nieves, Granada
  • Pablo Diaz-Calvillo Dermatology Unit. Hospital Universitario Virgen de las Nieves. Granada, Spain.
  • Juan-Angel Rodriguez-Pozo Dermatology Unit. Hospital Universitario Virgen de las Nieves. Granada, Spain.
  • Jesús Tercedor-Sánchez Dermatology Unit. Hospital Universitario Virgen de las Nieves. Granada. Spain
  • Maria-Rosa Cantudo-Cuenca Hospital Pharmacy Unit. Hospital Universitario Virgen de las Nieves. Granada, Spain.
  • Alejandro Molina-Leyva Dermatology Department, Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas 2, ES-18014 Granada,
  • Salvador Arias-Santiago Dermatology Unit. IBS Granada. Hospital Universitario Virgen de las Nieves. Granada, Spain

DOI:

https://doi.org/10.2340/actadv.v102.2036

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References

Strazzulla LC, Wang EHC, Avila L, Lo Sicco K, Brinster N, Christiano AM, et al. Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis. J Am Acad Dermatol 2018; 78: 1-12.

https://doi.org/10.1016/j.jaad.2017.04.1141

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Lalosevic J, Gajic-Veljic M, Bonaci-Nikolic B, Stojkovic Lalosevic M, Nikolic M. Combined intravenous pulse and topical corticosteroid therapy for severe alopecia areata in children: comparison of two regimens. Dermatol Ther 2019; 32: e13092.

https://doi.org/10.1111/dth.13092

Phan K, Ramachandran V, Sebaratnam DF. Methotrexate for alopecia areata: a systematic review and meta-analysis. J Am Acad Dermatol 2019; 80: 120-127.e2.

https://doi.org/10.1016/j.jaad.2018.06.064

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Kennedy Crispin M, Ko JM, Craiglow BG, Li S, Shankar G, Urban JR, et al. Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI insight 2016; 1: e89776.

https://doi.org/10.1172/jci.insight.89776

Liu LY, Craiglow BG, Dai F, King BA. Tofacitinib for the treatment of severe alopecia areata and variants: a study of 90 patients. J Am Acad Dermatol 2017; 76: 22-28.

https://doi.org/10.1016/j.jaad.2016.09.007

Yu D-A, Kim YE, Kwon O, Park H. Treatment outcome of oral tofacitinib and ruxolitinib in patients with alopecia areata: a systematic review and meta-analysis. Indian J Dermatol Venereol Leprol 2021; 87: 621-627.

https://doi.org/10.25259/IJDVL_975_19

Olsen EA, Canfield D. SALT II: A new take on the Severity of Alopecia Tool (SALT) for determining percentage scalp hair loss. J Am Acad Dermatol 2016; 75: 1268-1270.

https://doi.org/10.1016/j.jaad.2016.08.042

Liu LY, King BA. Tofacitinib for the treatment of severe alopecia areata in adults and adolescents. J Investig Dermatology Symp Proc 2018; 19: 18-20.

https://doi.org/10.1016/j.jisp.2017.10.003

Wollenhaupt J, Lee E-B, Curtis JR, Silverfield J, Terry K, Soma K, et al. Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study. Arthritis Res Ther 2019; 21: 89.

https://doi.org/10.1186/s13075-019-1866-2

Kurosawa M, Nakagawa S, Mizuashi M, Sasaki Y, Kawamura M, Saito M, et al. A comparison of the efficacy, relapse rate and side effects among three modalities of systemic corticosteroid therapy for alopecia areata. Dermatology 2006; 212: 361-265.

https://doi.org/10.1159/000092287

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Published

2022-06-15

How to Cite

Sanchez-Diaz, M., Diaz-Calvillo, P., Rodriguez-Pozo, J.-A., Tercedor-Sánchez, J., Cantudo-Cuenca, M.-R., Molina-Leyva, A., & Arias-Santiago, S. (2022). Tofacitinib for Treatment of Alopecia Areata: Real-world Evidence and Factors Associated with Therapeutic Response. Acta Dermato-Venereologica, 102, adv00736. https://doi.org/10.2340/actadv.v102.2036

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