Dupilumab Significantly Reduces Symptoms of Prurigo Nodularis and Depression: A Case Series

Authors

  • Louise Lönndahl Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 76, Stockholm, Sweden
  • Maria Lundqvist Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden, Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Maria Bradley Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden, Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • Emma K. Johansson Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden, Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

DOI:

https://doi.org/10.2340/actadv.v102.2151

Keywords:

prurigo nodularis, dupilumab, depression, filaggrin

Abstract

Abstract is missing (Short communication)

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References

Zeidler C, Yosipovitch G, Ständer S. Prurigo nodularis and its management. Dermatol Clin 2018; 36: 189-197.

https://doi.org/10.1016/j.det.2018.02.003

Williams KA, Roh YS, Brown I, Sutaria N, Bakhshi P, Choi J, et al. Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis. Expert Rev Clin Pharmacol 2021; 14: 67-77.

https://doi.org/10.1080/17512433.2021.1852080

Fukushi S, Yamasaki K, Aiba S. Nuclear localization of activated STAT6 and STAT3 in epidermis of prurigo nodularis. Br J Dermatol 2011; 165: 990-996.

https://doi.org/10.1111/j.1365-2133.2011.10498.x

Toffoli L, Farinazzo E, Zelin E, Agozzino M, Dianzani C, Di Meo N, et al. Dupilumab as promising treatment for prurigo nodularis: current evidences. J Dermatolog Treat 2021; 15: 1-6.

https://doi.org/10.1080/09546634.2021.1886232

Calugareanu A, Jachiet M, Tauber M, Nosbaum A, Aubin F, Misery L, et al. Effectiveness and safety of dupilumab for the treatment of prurigo nodularis in a French multicenter adult cohort of 16 patients. J Eur Acad Dermatol Venereol 2020; 34: 74-76.

https://doi.org/10.1111/jdv.15957

Sandilands A, Terron-Kwiatkowski A, Hull PR, O'Regan GM, Clayton TH, Watson RM, et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007; 39: 650-654.

https://doi.org/10.1038/ng2020

Janmohamed SR, Gwillim EC, Yousaf M, Patel KR, Silverberg JI. The impact of prurigo nodularis on quality of life: a systematic review and meta-analysis. Arch Dermatol Res 2021; 313: 669-677.

https://doi.org/10.1007/s00403-020-02148-0

Jørgensen KM, Egeberg A, Gislason GH, Skov L, Thyssen JP. Anxiety, depression and suicide in patients with prurigo nodularis. J Eur Acad Dermatol Venereol 2017; 31: 106-107.

https://doi.org/10.1111/jdv.13827

Fölster-Holst R, Reimer R, Neumann C, Proksch E, Rodriguez E, Weidinger S, et al. Comparison of epidermal barrier integrity in adults with classic atopic dermatitis, atopic prurigo and non-atopic prurigo nodularis. Biology (Basel) 2021; 10: 1008.

https://doi.org/10.3390/biology10101008

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Published

2022-08-11

How to Cite

Lönndahl, L., Lundqvist, M., Bradley, M., & Johansson, E. K. (2022). Dupilumab Significantly Reduces Symptoms of Prurigo Nodularis and Depression: A Case Series. Acta Dermato-Venereologica, 102, adv00754. https://doi.org/10.2340/actadv.v102.2151

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