Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

Authors

  • Shiro Niiyama
  • Yumiko Ishimatsu-Tsuji
  • Yosuke Nakazawa
  • Yuzo Yoshida
  • Tsutomu Soma
  • Ritsuro Ideta
  • Hideki Mukai
  • Jiro Kishimoto

DOI:

https://doi.org/10.2340/00015555-2949

Keywords:

alopecia, dermal papilla, GREM2, hair biology, TGF-b1.

Abstract

Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it has not yet been well characterized. This study investigated the gene expression profile of the intact dermal sheath cup, and identified dermal sheath cup signature genes, including extracellular matrix components and bone morphogenetic protein-binding molecules, as well as transforming frowth factor beta 1 as an upstream regulator. Among these, gremilin-2, a member of the bone morphogenetic protein antagonists, was found by in situ hybridization to be highly specific to the dermal sheath cup, implying that gremlin-2 is a key molecule contributing to maintenance of the properties of the dermal sheath cup.

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Published

2018-05-09

How to Cite

Niiyama, S., Ishimatsu-Tsuji, Y., Nakazawa, Y., Yoshida, Y., Soma, T., Ideta, R., … Kishimoto, J. (2018). Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles. Acta Dermato-Venereologica, 98(7), 694–698. https://doi.org/10.2340/00015555-2949

Issue

Vol. 98 No. 7 (2018): July

Section

Articles

License

Copyright (c) 2018 Shiro Niiyama, Yumiko Ishimatsu-Tsuji, Yosuke Nakazawa, Yuzo Yoshida, Tsutomu Soma, Ritsuro Ideta, Hideki Mukai, Jiro Kishimoto

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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