Novel Onset of Cutaneous Lupus Erythematosus Induced by Pembrolizumab
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https://doi.org/10.2340/actadv.v104.40801Keywords:
drug induced lupus erythematosus, immune checkpoint inhibitor, PD-L1 inhibitor, pembrolizumab, subacute cutaneous lupus erythematosusAbstract
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Grönhagen CM, Fored CM, Linder M, Granath F, Nyberg F. Subacute cutaneous lupus erythematosus and its association with drugs: a population-based matched case-control study of 234 patients in Sweden. Br J Dermatol 2012; 167: 296-305.
https://doi.org/10.1111/j.1365-2133.2012.10969.x DOI: https://doi.org/10.1111/j.1365-2133.2012.10969.x
Raschi E, Antonazzo IC, Poluzzi E, De Ponti F. Drug-induced systemic lupus erythematosus: should immune checkpoint inhibitors be added to the evolving list? Ann Rheum Dis 2021; 80: e120.
https://doi.org/10.1136/annrheumdis-2019-215819 DOI: https://doi.org/10.1136/annrheumdis-2019-215819
Haanen J, Ernstoff MS, Wang Y, Menzies AM, Puzanov I, Grivas P, et al. Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: review of the literature and personalized risk-based prevention strategy. Ann Oncol 2020; 31: 724-744.
https://doi.org/10.1016/j.annonc.2020.03.285 DOI: https://doi.org/10.1016/j.annonc.2020.03.285
Rong Y, Bentley JP, Bhattacharya K, Yang Y, Chang Y, Earl S, et al. Incidence and risk factors of immune-related adverse events induced by immune checkpoint inhibitors among older adults with non-small cell lung cancer. Cancer Med 2024; 13: e6879.
https://doi.org/10.1002/cam4.6879 DOI: https://doi.org/10.1002/cam4.6879
Bhardwaj M, Chiu MN, Sah SP. Adverse cutaneous toxicities by PD-1/PD-L1 immune checkpoint inhibitors: pathogenesis, treatment, and surveillance. Cutan Ocul Toxicol 2022; 41: 73-90.
https://doi.org/10.1080/15569527.2022.2034842 DOI: https://doi.org/10.1080/15569527.2022.2034842
Bolton C, Chen Y, Hawthorne R, Schepel IRM, Harriss E, Hofmann SC, et al. Systematic review: monoclonal antibody-induced subacute cutaneous lupus erythematosus. Drugs R D 2020; 20: 319-330.
https://doi.org/10.1007/s40268-020-00320-5 DOI: https://doi.org/10.1007/s40268-020-00320-5
Kosche C, Owen JL, Choi JN. Widespread subacute cutaneous lupus erythematosus in a patient receiving checkpoint inhibitor immunotherapy with ipilimumab and nivolumab. Dermatol Online J 2019; 25: 13030/qt4md713j8.
https://doi.org/10.5070/D32510045821 DOI: https://doi.org/10.5070/D32510045821
Shao K, McGettigan S, Elenitsas R, Chu EY. Lupus-like cutaneous reaction following pembrolizumab: an immune-related adverse event associated with anti-PD-1 therapy. J Cutan Pathol 2018; 45: 74-77.
https://doi.org/10.1111/cup.13059 DOI: https://doi.org/10.1111/cup.13059
Zitouni NB, Arnault JP, Dadban A, Attencourt C, Lok CC, Chaby G. Subacute cutaneous lupus erythematosus induced by nivolumab: two case reports and a literature review. Melanoma Res 2019; 29: 212-215.
https://doi.org/10.1097/CMR.0000000000000536 DOI: https://doi.org/10.1097/CMR.0000000000000536
Liu RC, Sebaratnam DF, Jackett L, Kao S, Lowe PM. Subacute cutaneous lupus erythematosus induced by nivolumab. Australas J Dermatol 2018; 59: e152-154.
https://doi.org/10.1111/ajd.12681 DOI: https://doi.org/10.1111/ajd.12681
Bui AN, Hirner J, Singer SB, Eberly-Puleo A, Larocca C, Lianet CG, et al. De novo subacute cutaneous lupus erythematosus-like eruptions in the setting of programmed death-1 or programmed death ligand-1 inhibitor therapy: clinicopathological correlation. Clin Exp Dermatol 2021; 46: 328-337.
https://doi.org/10.1111/ced.14449 DOI: https://doi.org/10.1111/ced.14449
Marano AL, Clarke JM, Morse MA, Shah A, Barrow W, Selim MA, et al. Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy. Br J Dermatol 2019; 181: 580-583.
https://doi.org/10.1111/bjd.17245 DOI: https://doi.org/10.1111/bjd.17245
Blakeway EA, Elshimy N, Muinonen-Martin A, Marples M, Bipin Mathew B, Mitra A. Cutaneous lupus associated with pembrolizumab therapy for advanced melanoma: a report of three cases. Melanoma Res 2019; 29: 338-341.
https://doi.org/10.1097/CMR.0000000000000587 DOI: https://doi.org/10.1097/CMR.0000000000000587
Andersson NW, Zachariae C, Simonsen AB. Late onset of subacute cutaneous lupus erythematosus following pembrolizumab therapy. Eur J Cancer 2021; 145: 168-170.
https://doi.org/10.1016/j.ejca.2020.12.017 DOI: https://doi.org/10.1016/j.ejca.2020.12.017
Gambichler T, Doerler M, Scheel CH. Onset of subacute cutaneous lupus erythematosus after the initiation of immune checkpoint inhibitor therapy of cancer. Lupus 2021; 30: 531-533.
https://doi.org/10.1177/0961203320983448 DOI: https://doi.org/10.1177/0961203320983448
Ogawa-Momohara M, Muro Y, Goto K, Obuse C, Satoh M, Kono M, et al. Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab. J Dermatol 2020;47: e217-e219.
https://doi.org/10.1111/1346-8138.15316 DOI: https://doi.org/10.1111/1346-8138.15316
Fietz S, Fröhlich A, Mauch C, de Vos-Hillebrand L, Fetter T, Landsberg J, et al. Manifestation of subacute cutaneous lupus erythematosus during treatment with anti-PD-1 antibody cemiplimab: a case report. Front Immunol 2023; 14: 1324231.
https://doi.org/10.3389/fimmu.2023.1324231 DOI: https://doi.org/10.3389/fimmu.2023.1324231
Diago A, Hueso L, Ara-Martín M, Abadías-Granado I. Subacute cutaneous lupus erythematosus induced by PD-1 Inhibitor therapy: two case reports and literature review. Australas J Dermatol 2021; 62: e347-349.
https://doi.org/10.1111/ajd.13538 DOI: https://doi.org/10.1111/ajd.13538
Manjunath J, Mochel M, Nutan F. Nivolumab-induced de novo discoid lupus erythematosus. Case Rep Dermatol 2022; 14: 88-92.
https://doi.org/10.1159/000523800 DOI: https://doi.org/10.1159/000523800
Khorasanchi A, Korman AM, Manne A, Meara A. Immune checkpoint inhibitor-induced subacute cutaneous lupus erythematosus: a case report and review of the literature. Front Med (Lausanne) 2024; 11: 1334718.
https://doi.org/10.3389/fmed.2024.1334718 DOI: https://doi.org/10.3389/fmed.2024.1334718
Kuhn A, Specker C, Ruzicka T, Lehmann P. Methotrexate treatment for refractory subacute cutaneous lupus erythematosus. J Am Acad Dermatol 2002; 46: 600-603.
https://doi.org/10.1067/mjd.2002.114608 DOI: https://doi.org/10.1067/mjd.2002.114608
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