Novel Onset of Cutaneous Lupus Erythematosus Induced by Pembrolizumab

Authors

  • Dimitrii Pogorelov Center for Dermatology, Allergology und Dermatosurgery, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany
  • Heribert Strotkötter Medical Care Centre for Outpatient Radiotherapy, Nuclear Medicine and Oncology, Helios Wuppertal, Wuppertal, Germany
  • Vesna Bjelic-Radisic Breast Unit, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany
  • Ulrich Wesselmann Center for Dermatology, Allergology und Dermatosurgery, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany
  • Jonas Hübinger Center for Dermatology, Allergology und Dermatosurgery, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany
  • Simona Sabulyte Center for Dermatology, Allergology und Dermatosurgery, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany
  • Silke C. Hofmann Center for Dermatology, Allergology und Dermatosurgery, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany https://orcid.org/0000-0002-4221-386X
  • Galina Balakirski Center for Dermatology, Allergology und Dermatosurgery, Helios University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany

DOI:

https://doi.org/10.2340/actadv.v104.40801

Keywords:

drug induced lupus erythematosus, immune checkpoint inhibitor, PD-L1 inhibitor, pembrolizumab, subacute cutaneous lupus erythematosus

Abstract

Abstract is missing (Short Communication)

Downloads

Download data is not yet available.

References

Grönhagen CM, Fored CM, Linder M, Granath F, Nyberg F. Subacute cutaneous lupus erythematosus and its association with drugs: a population-based matched case-control study of 234 patients in Sweden. Br J Dermatol 2012; 167: 296-305.

https://doi.org/10.1111/j.1365-2133.2012.10969.x DOI: https://doi.org/10.1111/j.1365-2133.2012.10969.x

Raschi E, Antonazzo IC, Poluzzi E, De Ponti F. Drug-induced systemic lupus erythematosus: should immune checkpoint inhibitors be added to the evolving list? Ann Rheum Dis 2021; 80: e120.

https://doi.org/10.1136/annrheumdis-2019-215819 DOI: https://doi.org/10.1136/annrheumdis-2019-215819

Haanen J, Ernstoff MS, Wang Y, Menzies AM, Puzanov I, Grivas P, et al. Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: review of the literature and personalized risk-based prevention strategy. Ann Oncol 2020; 31: 724-744.

https://doi.org/10.1016/j.annonc.2020.03.285 DOI: https://doi.org/10.1016/j.annonc.2020.03.285

Rong Y, Bentley JP, Bhattacharya K, Yang Y, Chang Y, Earl S, et al. Incidence and risk factors of immune-related adverse events induced by immune checkpoint inhibitors among older adults with non-small cell lung cancer. Cancer Med 2024; 13: e6879.

https://doi.org/10.1002/cam4.6879 DOI: https://doi.org/10.1002/cam4.6879

Bhardwaj M, Chiu MN, Sah SP. Adverse cutaneous toxicities by PD-1/PD-L1 immune checkpoint inhibitors: pathogenesis, treatment, and surveillance. Cutan Ocul Toxicol 2022; 41: 73-90.

https://doi.org/10.1080/15569527.2022.2034842 DOI: https://doi.org/10.1080/15569527.2022.2034842

Bolton C, Chen Y, Hawthorne R, Schepel IRM, Harriss E, Hofmann SC, et al. Systematic review: monoclonal antibody-induced subacute cutaneous lupus erythematosus. Drugs R D 2020; 20: 319-330.

https://doi.org/10.1007/s40268-020-00320-5 DOI: https://doi.org/10.1007/s40268-020-00320-5

Kosche C, Owen JL, Choi JN. Widespread subacute cutaneous lupus erythematosus in a patient receiving checkpoint inhibitor immunotherapy with ipilimumab and nivolumab. Dermatol Online J 2019; 25: 13030/qt4md713j8.

https://doi.org/10.5070/D32510045821 DOI: https://doi.org/10.5070/D32510045821

Shao K, McGettigan S, Elenitsas R, Chu EY. Lupus-like cutaneous reaction following pembrolizumab: an immune-related adverse event associated with anti-PD-1 therapy. J Cutan Pathol 2018; 45: 74-77.

https://doi.org/10.1111/cup.13059 DOI: https://doi.org/10.1111/cup.13059

Zitouni NB, Arnault JP, Dadban A, Attencourt C, Lok CC, Chaby G. Subacute cutaneous lupus erythematosus induced by nivolumab: two case reports and a literature review. Melanoma Res 2019; 29: 212-215.

https://doi.org/10.1097/CMR.0000000000000536 DOI: https://doi.org/10.1097/CMR.0000000000000536

Liu RC, Sebaratnam DF, Jackett L, Kao S, Lowe PM. Subacute cutaneous lupus erythematosus induced by nivolumab. Australas J Dermatol 2018; 59: e152-154.

https://doi.org/10.1111/ajd.12681 DOI: https://doi.org/10.1111/ajd.12681

Bui AN, Hirner J, Singer SB, Eberly-Puleo A, Larocca C, Lianet CG, et al. De novo subacute cutaneous lupus erythematosus-like eruptions in the setting of programmed death-1 or programmed death ligand-1 inhibitor therapy: clinicopathological correlation. Clin Exp Dermatol 2021; 46: 328-337.

https://doi.org/10.1111/ced.14449 DOI: https://doi.org/10.1111/ced.14449

Marano AL, Clarke JM, Morse MA, Shah A, Barrow W, Selim MA, et al. Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy. Br J Dermatol 2019; 181: 580-583.

https://doi.org/10.1111/bjd.17245 DOI: https://doi.org/10.1111/bjd.17245

Blakeway EA, Elshimy N, Muinonen-Martin A, Marples M, Bipin Mathew B, Mitra A. Cutaneous lupus associated with pembrolizumab therapy for advanced melanoma: a report of three cases. Melanoma Res 2019; 29: 338-341.

https://doi.org/10.1097/CMR.0000000000000587 DOI: https://doi.org/10.1097/CMR.0000000000000587

Andersson NW, Zachariae C, Simonsen AB. Late onset of subacute cutaneous lupus erythematosus following pembrolizumab therapy. Eur J Cancer 2021; 145: 168-170.

https://doi.org/10.1016/j.ejca.2020.12.017 DOI: https://doi.org/10.1016/j.ejca.2020.12.017

Gambichler T, Doerler M, Scheel CH. Onset of subacute cutaneous lupus erythematosus after the initiation of immune checkpoint inhibitor therapy of cancer. Lupus 2021; 30: 531-533.

https://doi.org/10.1177/0961203320983448 DOI: https://doi.org/10.1177/0961203320983448

Ogawa-Momohara M, Muro Y, Goto K, Obuse C, Satoh M, Kono M, et al. Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab. J Dermatol 2020;47: e217-e219.

https://doi.org/10.1111/1346-8138.15316 DOI: https://doi.org/10.1111/1346-8138.15316

Fietz S, Fröhlich A, Mauch C, de Vos-Hillebrand L, Fetter T, Landsberg J, et al. Manifestation of subacute cutaneous lupus erythematosus during treatment with anti-PD-1 antibody cemiplimab: a case report. Front Immunol 2023; 14: 1324231.

https://doi.org/10.3389/fimmu.2023.1324231 DOI: https://doi.org/10.3389/fimmu.2023.1324231

Diago A, Hueso L, Ara-Martín M, Abadías-Granado I. Subacute cutaneous lupus erythematosus induced by PD-1 Inhibitor therapy: two case reports and literature review. Australas J Dermatol 2021; 62: e347-349.

https://doi.org/10.1111/ajd.13538 DOI: https://doi.org/10.1111/ajd.13538

Manjunath J, Mochel M, Nutan F. Nivolumab-induced de novo discoid lupus erythematosus. Case Rep Dermatol 2022; 14: 88-92.

https://doi.org/10.1159/000523800 DOI: https://doi.org/10.1159/000523800

Khorasanchi A, Korman AM, Manne A, Meara A. Immune checkpoint inhibitor-induced subacute cutaneous lupus erythematosus: a case report and review of the literature. Front Med (Lausanne) 2024; 11: 1334718.

https://doi.org/10.3389/fmed.2024.1334718 DOI: https://doi.org/10.3389/fmed.2024.1334718

Kuhn A, Specker C, Ruzicka T, Lehmann P. Methotrexate treatment for refractory subacute cutaneous lupus erythematosus. J Am Acad Dermatol 2002; 46: 600-603.

https://doi.org/10.1067/mjd.2002.114608 DOI: https://doi.org/10.1067/mjd.2002.114608

Additional Files

Published

2024-09-30

How to Cite

Pogorelov, D., Strotkötter, H., Bjelic-Radisic, V., Wesselmann, U., Hübinger, J., Sabulyte, S., … Balakirski, G. (2024). Novel Onset of Cutaneous Lupus Erythematosus Induced by Pembrolizumab. Acta Dermato-Venereologica, 104, adv40801. https://doi.org/10.2340/actadv.v104.40801

Issue

Section

Short Communication

Categories