A 4-year-old Boy with a Red Nodule on His Hand: A Quiz

Authors

  • Riku Ishii Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
  • Noriyuki Otsuka Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan
  • Takashi Anan Sapporo Dermatopathology Institute, Sapporo, Japan
  • Yuhei Yamamoto Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
  • Taku Maeda Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

DOI:

https://doi.org/10.2340/actadv.v105.41071

Keywords:

Atypical Spitz tumor, ALK, ALK fusion, Sentinel lymph node biopsy

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References

Yeh I, de la Fouchardiere A, Pissaloux D, Mully TW, Garrido MC, Vemula SS, et al. Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions. Am J Surg Pathol 2015; 39: 581–591.

https://doi.org/10.1097/PAS.0000000000000387 DOI: https://doi.org/10.1097/PAS.0000000000000387

Dal Pozzo CA, Cappellesso R. The morpho-molecular landscape of spitz neoplasms. Int J Mol Sci 2022; 23: 4211.

https://doi.org/10.3390/ijms23084211 DOI: https://doi.org/10.3390/ijms23084211

Chung CT, Marrano P, Swanson D, Dickson BC, Thorner PS. Fusion of ALK to the melanophilin gene MLPH in pediatric Spitz nevi. Hum Pathol 2019; 87: 57–64.

https://doi.org/10.1016/j.humpath.2019.03.002 DOI: https://doi.org/10.1016/j.humpath.2019.03.002

Busam KJ, Kutzner H, Cerroni L, Wiesner T. Clinical and patho-logic findings of Spitz nevi and atypical Spitz tumors with ALK fusions. Am J Surg Pathol 2014; 38: 925–933.

https://doi.org/10.1097/PAS.0000000000000187 DOI: https://doi.org/10.1097/PAS.0000000000000187

Kastnerova L, Martinek P, Grossmann P, Steiner P, Vanecek T, Kyclova J, et al. A clinicopathological study of 29 spitzoid melanocytic lesions with ALK fusions, including novel fusion variants, accompanied by fluorescence in situ hybridization analysis for chromosomal copy number changes, and both TERT promoter and next-generation sequencing mutation analysis. Am J Dermatopathol 2020; 42: 578–592.

https://doi.org/10.1097/DAD.0000000000001632 DOI: https://doi.org/10.1097/DAD.0000000000001632

Bahrani E, Kunder CA, Teng JM, Brown RA, Rieger KE, Novoa RA, et al. Spitz nevus with EHBP1-ALK fusion and distinctive membranous localization of ALK. J Cutan Pathol 2022; 49: 584–588.

https://doi.org/10.1111/cup.14209 DOI: https://doi.org/10.1111/cup.14209

Salah HT, Yang RK, Roy-Chowdhuri S, Ross MI, Aung PP, Rothrock AT, et al. Spitz melanocytic neoplasms with MLPH::ALK fusions: report of two cas-es with previously unreported features and literature review. J Cutan Pathol 2024; 51: 407–414.

https://doi.org/10.1111/cup.14605 DOI: https://doi.org/10.1111/cup.14605

Cho WC, Prieto VG, Yang RK. Spitz melanoma with SLC20A1::ALK fusion: a novel fusion previously undescribed in spitz melanocytic neoplasm. Am J Dermatopathol 2024; 46: 700–703.

https://doi.org/10.1097/DAD.0000000000002778 DOI: https://doi.org/10.1097/DAD.0000000000002778

Lallas A, Kyrgidis A, Ferrara G, Kittler H, Apalla Z, Castagnetti F, et al. Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review. Lancet Oncol 2014; 15: e178–183.

https://doi.org/10.1016/S1470-2045(13)70608-9 DOI: https://doi.org/10.1016/S1470-2045(13)70608-9

Cerrato F, Wallins JS, Webb ML, McCarty ER, Schmidt BA, Labow BI. Outcomes in pediatric atypical spitz tumors treated without sentinel lymph node biopsy. Pediatr Dermatol 2012; 29: 448–453.

https://doi.org/10.1111/j.1525-1470.2011.01699.x DOI: https://doi.org/10.1111/j.1525-1470.2011.01699.x

Published

2025-01-28

How to Cite

Ishii, R., Otsuka, N., Anan, T., Yamamoto, Y., & Maeda, T. (2025). A 4-year-old Boy with a Red Nodule on His Hand: A Quiz. Acta Dermato-Venereologica, 105, adv41071. https://doi.org/10.2340/actadv.v105.41071

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