Severe Acute Generalized Exanthematous Pustulosis Successfully Treated by Spesolimab

Authors

  • Giuseppe Russo Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland
  • Shireen Dumont Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland
  • Sébastien Menzinger Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland; Department of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland
  • Damien Pastor Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland
  • Laurence Toutous Trellu Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland
  • Gürkan Kaya Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland; Department of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland
  • Emmanuel Laffitte Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland

DOI:

https://doi.org/10.2340/actadv.v104.41311

Keywords:

AGEP, Spesolimab, IL-36

Abstract

Abstract is missing (Short communication)

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References

Hotz C, Valeyrie-Allanore L, Haddad C, Bouvresse S, Ortonne N, Duong TA, et al. Systemic involvement of acute generalized exanthematous pustulosis: a retrospective study on 58 patients. Br J Dermatol 2013; 169: 1223-1232.

https://doi.org/10.1111/bjd.12502 DOI: https://doi.org/10.1111/bjd.12502

Parisi R, Shah H, Navarini AA, Muehleisen B, Ziv M, Shear NH, et al. Acute generalized exanthematous pustulosis: clinical features, differential diagnosis, and management. Am J Clin Dermatol 2023; 24: 557-575.

https://doi.org/10.1007/s40257-023-00779-3 DOI: https://doi.org/10.1007/s40257-023-00779-3

Feldmeyer L, Heidemeyer K, Yawalkar N. Acute generalized exanthematous pustulosis: pathogenesis, genetic background, clinical variants and therapy. Int J Mol Sci 2016; 17: 1214.

https://doi.org/10.3390/ijms17081214 DOI: https://doi.org/10.3390/ijms17081214

Meier-Schiesser B, Feldmeyer L, Jankovic D, Mellett M, Satoh TK, Yerly D, et al. Culprit drugs induce specific IL-36 overexpression in acute generalized exanthematous pustulosis. J Invest Dermatol 2019; 139: 848-858.

https://doi.org/10.1016/j.jid.2018.10.023 DOI: https://doi.org/10.1016/j.jid.2018.10.023

Navarini AA, Simpson MA, Borradori L, Yawalkar N, Schlapbach C. Homozygous missense mutation in IL36RN in generalized pustular dermatosis with intraoral involvement compatible with both AGEP and generalized pustular psoriasis. JAMA Dermatol 2015; 151: 452-453.

https://doi.org/10.1001/jamadermatol.2014.3848 DOI: https://doi.org/10.1001/jamadermatol.2014.3848

Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, et al. Trial of spesolimab for generalized pustular psoriasis. N Engl J Med 2021; 385: 2431-2440.

https://doi.org/10.1056/NEJMoa2111563 DOI: https://doi.org/10.1056/NEJMoa2111563

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Published

2024-09-11

How to Cite

Russo, G., Dumont, S., Menzinger, S., Pastor, D., Toutous Trellu, L., Kaya, G., & Laffitte, E. (2024). Severe Acute Generalized Exanthematous Pustulosis Successfully Treated by Spesolimab. Acta Dermato-Venereologica, 104, adv41311. https://doi.org/10.2340/actadv.v104.41311

Issue

Vol. 104 (2024)

Section

Short Communication

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Copyright (c) 2024 Giuseppe Russo, Shireen Dumont, Sébastien Menzinger, Damien Pastor, Laurence Toutous Trellu, Gürkan Kaya, Emmanuel Laffitte

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