Associations of Atopic Dermatitis in Late Adolescence with Occupation, Mental Health, Income from Work and Marital Status: A National Longitudinal Study
DOI:
https://doi.org/10.2340/actadv.v105.42127Keywords:
Atopic dermatitis, Epidemiology, Quality of LifeAbstract
The main aim of this study was to evaluate longitudinal associations between atopic dermatitis (AD) in late adolescence and occupational socioeconomic group, labour market participation, income from work, and marital status later in adult life. Using Swedish population-based registry data a total of 205,394 men were included, born between 1952 and 1956 in Sweden and who underwent military conscription examination including assessment of atopic dermatitis (AD) and AD severity. The associations between AD and AD severity in late adolescence and labour market participation, income from work, marital status, and medication for anxiety and depression later in adult life were examined. In this study, men with AD in adolescence, especially those with severe AD, more often had a prescription for antidepressants or anxiolytics at the age of 50–57 years (unadjusted HR 1.55, 95% CI 1.32–1.81). Interestingly, despite increased risk of poorer mental health, AD was not found to be associated with a disadvantage in terms of occupational socioeconomic group, income from work, and unemployment benefits. Individuals with mild AD showed a lower risk of holding routine and lower technical jobs compared with men without AD. Persons with AD in late adolescence seem not to differ regarding registered partnerships and marital status compared with those without AD.
Downloads
References
Bylund S, Kobyletzki LB, Svalstedt M, Svensson Å. Prevalence and incidence of atopic dermatitis a systematic review. Acta Derm Venereol 2020; 100: adv00160.
https://doi.org/10.2340/00015555-3510 DOI: https://doi.org/10.2340/00015555-3510
Silverberg JI, Barbarot S, Gadkari A, Simpson, EL, Weidinger, S., Mina-Osorio, P. et al. Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study. Ann Allergy Asthma Immunol 2021; 126:417-428 e412.
https://doi.org/10.1016/j.anai.2020.12.020 DOI: https://doi.org/10.1016/j.anai.2020.12.020
Sandstrom MH and Faergemann J. Prognosis and prognostic factors in adult patients with atopic dermatitis: a long-term follow-up questionnaire study. Br J Dermatol 2004; 150: 103-110.
https://doi.org/10.1111/j.1365-2133.2004.05711.x DOI: https://doi.org/10.1111/j.1365-2133.2004.05711.x
Kim JP, Chao LX, Simpson EL, Silverberg JI, . Persistence of atopic dermatitis (AD): A systematic review and meta-analysis. J Am Acad Dermatol 2016; 75: 681-687 e611.
https://doi.org/10.1016/j.jaad.2016.05.028 DOI: https://doi.org/10.1016/j.jaad.2016.05.028
von Kobyletzki LB, Bornehag CG, Breeze E, Larsson M, Lindström CB, Svensson Å Factors associated with remission of eczema in children: a population-based study. Acta Derm Venereol 2014; 94: 179-184
https://doi.org/10.2340/00015555-1681 DOI: https://doi.org/10.2340/00015555-1681
Barbarot S, Auziere S, Gadkari A, Girolomoni G, Puig L, Simpson, EL. et al. Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy 2018;73;1284-1293.
https://doi.org/10.1111/all.13401 DOI: https://doi.org/10.1111/all.13401
Ganemo A, Svensson A, Lindberg M, Wahlgren CF. Quality of life in Swedish children with eczema. Acta Derm Venereol 2007; 87: 345-349.
https://doi.org/10.2340/00015555-0245 DOI: https://doi.org/10.2340/00015555-0245
Chamlin SL, Chren MM. Quality-of-life outcomes and measurement in childhood atopic dermatitis. Immunol Allergy Clin North Am 2010; 30: 281-288.
https://doi.org/10.1016/j.iac.2010.05.004 DOI: https://doi.org/10.1016/j.iac.2010.05.004
Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureski AA. The burden of atopic dermatitis: Summary of a report for the National Eczema Association. J Invest Dermatol 2017; 137: 26-30.
https://doi.org/10.1016/j.jid.2016.07.012 DOI: https://doi.org/10.1016/j.jid.2016.07.012
Dalgard FJ, Gieler U, Tomas-Aragones L, Lien L, Poot F, Jemec GBE, et al. The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries. J Invest Dermatol 2015; 135: 984-991.
https://doi.org/10.1038/jid.2014.530 DOI: https://doi.org/10.1038/jid.2014.530
Zink AGS, Arents B, Fink-Wagner A, Seitz IA, Mensing U, Wettemann N, et al. Out-of-pocket Costs for Individuals with Atopic Eczema: A Cross-sectional Study in Nine European Countries. Acta Derm Venereol 2019; 99: 263-267.
https://doi.org/10.2340/00015555-3102 DOI: https://doi.org/10.2340/00015555-3102
Chung J and Simpson EL. The socioeconomics of atopic dermatitis. Ann Allergy Asthma Immunol 2019; 122: 360-366.
https://doi.org/10.1016/j.anai.2018.12.017 DOI: https://doi.org/10.1016/j.anai.2018.12.017
Thyssen JP, Brenneche AW, Madsen ME, Pedersen MH, Trangbaek DJ, Vestergaard C. Societal Costs of Moderate-to-severe Atopic Dermatitis Occurring in Adulthood: A Danish Register-based Study. Acta Derm Venereol 2021; 101: adv00538.
https://doi.org/10.2340/00015555-3908 DOI: https://doi.org/10.2340/00015555-3908
von Kobyletzki LB, Bornehag CG, Hasselgren M, Larsson M, Lindström CB, Svensson Å. Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort. BMC Dermatol 2012; 12: 11.
https://doi.org/10.1186/1471-5945-12-11 DOI: https://doi.org/10.1186/1471-5945-12-11
Rønnstad ATM, Halling-Overgaard AS, Hamann CR, Skov L, Egeberg A, Thyssen JP. Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: a systematic review and meta-analysis. J Am Acad Dermatol 2018; 79: 448-445.
https://doi.org/10.1016/j.jaad.2018.03.017 DOI: https://doi.org/10.1016/j.jaad.2018.03.017
Sato Y, Hiyoshi A, Melinder C, Suzuki C, Montgomery S. Asthma and atopic diseases in adolescence and antidepressant medication in middle age. J Health Psychol 2018; 23: 853-859.
https://doi.org/10.1177/1359105316660181 DOI: https://doi.org/10.1177/1359105316660181
Dieris-Hirche J, Gieler U, Petrak F, Milch W, Te Wildt B, Dieris B et al. Suicidal ideation in adult patients with atopic dermatitis: a German cross-sectional study. Acta Derm Venereol 2017; 97: 1189-1195.
https://doi.org/10.2340/00015555-2741 DOI: https://doi.org/10.2340/00015555-2741
Thyssen JP, Hamann CR, Linneberg A, Dantoft TM, Skov L, Gislason GH et al. Atopic dermatitis is associated with anxiety, depression, and suicidal ideation, but not with psychiatric hospitalization or suicide. Allergy 2018; 73: 214-220.
https://doi.org/10.1111/all.13231 DOI: https://doi.org/10.1111/all.13231
Hiyoshi A, Sabet JA, Sjöqvist H, Melinder C, Brummer RJ, Montgomery S. Precursors in adolescence of adult-onset bipolar disorder. J Affect Disord. 2017; 218:353-358.
https://doi.org/10.1016/j.jad.2017.04.071 DOI: https://doi.org/10.1016/j.jad.2017.04.071
Smirnova J, von Kobyletzki LB, Lindberg M, Svensson Å, Langan SM, Montgomery S. Atopic dermatitis, educational attainment and psychological functioning: a national cohort study. Br J Dermatol 2019; 180: 559-564.
https://doi.org/10.1111/bjd.17330 DOI: https://doi.org/10.1111/bjd.17330
Pálsson K, Slagor RM, Flachs EM, Norreslet LB, Agner T, Ebbehoj NE. Childhood atopic dermatitis is associated with a decreased chance of completing education later in life: a register-based cohort study. J Eur Acad Dermatol Venereol 2021; 35: 1849-1858.
https://doi.org/10.1111/jdv.17346 DOI: https://doi.org/10.1111/jdv.17346
Theodosiou G, Montgomery S, Metsini A, Dalgard FJ, Svensson Å, von Kobyletzki L. Burden of atopic dermatitis in swedish adults: a population-based study. Acta Derm Venereol 2019; 99: 964-970.
https://doi.org/10.2340/00015555-3257 DOI: https://doi.org/10.2340/00015555-3257
Sybilski AJ, Raciborski F, Lipiec A, Tomaszewska A, Lusawa A, Samel-Kowalik P et al. Epidemiology of atopic dermatitis in Poland according to the Epidemiology of Allergic Disorders in Poland (ECAP) study. J Dermatol 2015; 42: 140-147.
https://doi.org/10.1111/1346-8138.12731 DOI: https://doi.org/10.1111/1346-8138.12731
Hammer-Helmich L, Linneberg A, Thomsen SF, Glümer C. Association between parental socioeconomic position and prevalence of asthma, atopic eczema and hay fever in children. Scand J Public Health 2014; 42: 120-127
https://doi.org/10.1177/1403494813505727 DOI: https://doi.org/10.1177/1403494813505727
Hiyoshi A, Udumyan R, Osika W, Bihagen E, Fall K, Montgomery S. Stress resilience in adolescence and subsequent antidepressant and anxiolytic medication in middle aged men: Swedish cohort study. Soc Sci Med 2015; 134: 43-49.
https://doi.org/10.1016/j.socscimed.2015.03.057 DOI: https://doi.org/10.1016/j.socscimed.2015.03.057
Norreslet LB, Ebbehoj NE, Ellekilde Bonde JP, Thomsen SF, Agner T. The impact of atopic dermatitis on work life - a systematic review. J Eur Acad Dermatol Venereol 2018; 32: 23-38.
https://doi.org/10.1111/jdv.14523 DOI: https://doi.org/10.1111/jdv.14523
Matthews T, Danese A, Wertz J, Odgers CL, Ambler A, Moffitt TE et al. Social isolation, loneliness and depression in young adulthood: a behavioural genetic analysis. Soc Psychiatry Psychiatr Epidemiol 2016; 51: 339-348.
https://doi.org/10.1007/s00127-016-1178-7 DOI: https://doi.org/10.1007/s00127-016-1178-7
Hall JM, Cruser D, Podawiltz A, Mummert DI, Jones H, Mummert ME. Psychological stress and the cutaneous immune response: roles of the HPA axis and the sympathetic nervous system in atopic dermatitis and psoriasis. Dermatol Res Pract 2012; 2012: 403908.
https://doi.org/10.1155/2012/403908 DOI: https://doi.org/10.1155/2012/403908
Lomholt G. Prevalence of skin diseases in a population: a census study from the Faroe Islands. Dan Med Bull 1964; 11: 1-7.
Damush TM, Jia H, Ried LD, Qin H, Cameon R, Plue L, Williams LS. Case-finding algorithm for post-stroke depression in the veterans health administration. Int J Geriatr Psychiatry 2008; 23: 517-552.
https://doi.org/10.1002/gps.1930 DOI: https://doi.org/10.1002/gps.1930
Billari, F., Liefbroer, A. C., & Philipov, D. The postponement of childbearing in Europe: Driving forces and implications. Vienna Yearbook of Population Research 2006; 4: 1-17.
https://doi.org/10.1553/populationyearbook2006s1 DOI: https://doi.org/10.1553/populationyearbook2006s1
Schellekens J, Gliksberg D. The decline in marriage in Israel, 1960-2007: period or cohort effect? Eur J Popul 2018; 34: 119-142.
https://doi.org/10.1007/s10680-017-9457-x DOI: https://doi.org/10.1007/s10680-017-9457-x
Schellekens, J. The marriage boom and marriage bust in the United States: An age-period-cohort analysis. Popul Stud 2017; 71: 65-82.
https://doi.org/10.1080/00324728.2016.1271140 DOI: https://doi.org/10.1080/00324728.2016.1271140
Additional Files
Published
How to Cite
License
Copyright (c) 2025 Grigorios Theodosiou, Therese Sterner, Ayako Hiyoshi, Michael Carlberg, Åke Svensson, Scott Montgomery, Laura von Kobyletzki

This work is licensed under a Creative Commons Attribution 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
