Chronic Hand Eczema, Real World, and Patient Centricity: A Narrative Review

Authors

  • Sonja Molin Division of Dermatology, Queen's University, Kingston, Canada; Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany
  • Emma Guttman-Yassky Icahn School of Medicine at Mount Sinai, New York, USA
  • Jacob P. Thyssen LEO Pharma A/S, Ballerup, Denmark and Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark
  • Anthony Bewley Barts Health NHS Trust & QMUL, London, United Kingdom

DOI:

https://doi.org/10.2340/actadv.v105.42596

Keywords:

allergic contact dermatitis, occupational contact dermatitis., chronic hand eczema, health related quality of life

Abstract

Chronic hand eczema is a multifactorial, fluctuating, inflammatory skin disease of the hands and wrists, defined as hand eczema that persists for at least 3 months or recurs at least twice within 1 year. Chronic hand eczema is heterogeneous in nature with different clinical manifestations. This chronic condition can significantly impact daily activities and health-related quality of life for patients, including notable physical, psychosocial, occupational, and socioeconomic burdens. However, awareness of the disease and the patient experience remains poor. This review aims to improve understanding of chronic hand eczema in the context of its underlying pathogenesis, clinical subtypes and presentation, and risk factors. Additionally, an overview of the patient experience of the disease, including health-related quality of life and socioeconomic implications, is provided. Improved understanding of chronic hand eczema will support optimal patient care by empowering healthcare providers to more quickly and correctly diagnose this disease with high unmet treatment needs and subsequently offer appropriate holistic care.

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Published

2025-04-02

How to Cite

Molin, S., Guttman-Yassky, E., P. Thyssen, J., & Bewley, A. (2025). Chronic Hand Eczema, Real World, and Patient Centricity: A Narrative Review. Acta Dermato-Venereologica, 105, adv42596. https://doi.org/10.2340/actadv.v105.42596

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