A Threefold Association Between Vitiligo and Alopecia Areata: Results from a Nationwide Case-control Observational Study

Authors

  • Yonit Wohl Faculty of Medicine, Ariel University, Israel; Maccabi Health Services, Tel-Aviv, Israel; Kahn Sagol Maccabi Research and Innovation Center, Maccabi Healthcare Services, Tel-Aviv, Israel
  • Amir Bentov Maccabi Health Services, Tel-Aviv, Israel; Pediatrics Department, Dana-Dwek Children's Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; University Hospital Center of Tours, Department of Dermatology, Unit of Pediatric Dermatology, Tours, France
  • Yarden Drutin Pediatrics Department, Dana-Dwek Children's Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
  • Annabel Maruani University Hospital Center of Tours, Department of Dermatology, Unit of Pediatric Dermatology, Tours, France
  • Jacob Mashiah The Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel; Division of Dermatology, Pediatric Dermatology Unit, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Dermatology and Reference Center for Genodermatoses and Rare Skin Diseases (MAGEC), AP-HP, Necker-Enfants Malades Hospital, Paris, France

DOI:

https://doi.org/10.2340/actadv.v105.42819

Keywords:

alopecia areata, Vitiligo, autoimmune disease, epidemiology, JAK inhibitors

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References

Yamaguchi HL, Yamaguchi Y, Peeva E. Pathogenesis of alopecia areata and vitiligo: commonalities and differences. Int J Mol Sci 2024; 25: 4409.

https://doi.org/10.3390/ijms25084409 DOI: https://doi.org/10.3390/ijms25084409

Silverberg N. The genetics of pediatric cutaneous autoimmunity: The sister diseases vitiligo and alopecia areata. Clin Dermatol 2022; 40: 363-373.

https://doi.org/10.1016/j.clindermatol.2022.02.009 DOI: https://doi.org/10.1016/j.clindermatol.2022.02.009

Sun C, Ding H, Zhang L, Wang J, Su M. Co-regulatory mechanisms and potential markers of oxidative stress-related genes in vitiligo and alopecia areata. Skin Res Technol 2024; 30: e70001.

https://doi.org/10.1111/srt.70001 DOI: https://doi.org/10.1111/srt.70001

Ly S, Manjaly P, Kamal K, Shields A, Wafae B, Afzal N, et al. Comorbid conditions associated with alopecia areata: A systematic review and meta-analysis. Am J Clin Dermatol 2023; 24: 875-893.

https://doi.org/10.1007/s40257-023-00805-4 DOI: https://doi.org/10.1007/s40257-023-00805-4

Laitinen I, Jokelainen J, Tasanen K, Huijala L. Comorbidities of alopecia areata in Finland between 1987 and 2016. Acta Derm Venereol 2020; 100: adv00063.

https://doi.org/10.2340/00015555-3412 DOI: https://doi.org/10.2340/00015555-3412

Lee JH, Ju HJ, Seo JM, Almurayshid A, Kim GM, Ezzedine K, et al. Comorbidities in patients with vitiligo: A systematic review and meta-Analysis. J Invest Dermatol 2023; 143: 777-789.

https://doi.org/10.1016/j.jid.2022.10.021 DOI: https://doi.org/10.1016/j.jid.2022.10.021

King B, Zhang X, Harcha WG, Szepietowski JC, Shapiro J, Lynde C, et al. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b-3 trial. Lancet 2023; 401: 1518-1529.

https://doi.org/10.1016/S0140-6736(23)00222-2 DOI: https://doi.org/10.1016/S0140-6736(23)00222-2

Moya EC, Bruinsma RL, Kelly KA, Feldman SR. How suitable are JAK inhibitors in treating the inflammatory component in patients with alopecia areata and vitiligo? Expert Rev Clin Immunol 2022; 18: 189-191.

https://doi.org/10.1080/1744666X.2022.2036607 DOI: https://doi.org/10.1080/1744666X.2022.2036607

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Published

2025-02-05

How to Cite

Wohl, Y., Bentov, A., Drutin, Y., Maruani, A., & Mashiah, J. (2025). A Threefold Association Between Vitiligo and Alopecia Areata: Results from a Nationwide Case-control Observational Study. Acta Dermato-Venereologica, 105, adv42819. https://doi.org/10.2340/actadv.v105.42819

Issue

Vol. 105 (2025)

Section

Research letter

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Copyright (c) 2025 Yonit Wohl, Amir Bentov, Yarden Drutin, Annabel Maruani, Jacob Mashiah

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