Effectiveness and Safety of Spesolimab in Patients with Generalized Pustular Psoriasis: A Single-centre Retrospective Study

Authors

  • Yoshiki Okada Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
  • Masahiro Kamata Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
  • Kotaro Hayashi Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
  • Kazumitsu Sugiura Department of Dermatology, Fujita Health University, Toyoake, Japan
  • Yayoi Tada Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan

DOI:

https://doi.org/10.2340/actadv.v105.42879

Keywords:

psoriasis, generalized pustular psoriasis, spesolimab, interleukin-36, GPPASI, JDA severity score, GPPGA

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References

Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, et al. Trial of Spesolimab for Generalized Pustular Psoriasis. N Engl J Med 2021; 385: 2431-2440.

https://doi.org/10.1056/NEJMoa2111563 DOI: https://doi.org/10.1056/NEJMoa2111563

Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, et al. Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP. J Dermatol 2018; 45: 1235-1270.

https://doi.org/10.1111/1346-8138.14523 DOI: https://doi.org/10.1111/1346-8138.14523

Suzuki S, Kamata M, Ito M, Watanabe A, Uchida H, Chijiwa C, et al. Spesolimab improved pustules on the palms and soles that were refractory to tumor necrosis factor inhibitors and interleukin-17 inhibitors in a patient with generalized pustular psoriasis: A case report. J Dermatol 2024; 51: e416-e418.

https://doi.org/10.1111/1346-8138.17337 DOI: https://doi.org/10.1111/1346-8138.17337

Nakajima H, Kamata M, Okada Y, Ito M, Watanabe A, Azuma S, et al. Erythema multiforme after initiating spesolimab in a patient with generalized pustular psoriasis with IL36RN mutation. Eur J Dermatol 2024; 34: 324-325.

https://doi.org/10.1684/ejd.2024.4711 DOI: https://doi.org/10.1684/ejd.2024.4711

Nagata M, Kamata M, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, et al. Real-world single-center experience with 10 cases of generalized pustular psoriasis successfully treated with ixekizumab. J Am Acad Dermatol 2020; 82: 758-761.

https://doi.org/10.1016/j.jaad.2019.09.040 DOI: https://doi.org/10.1016/j.jaad.2019.09.040

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Published

2025-02-05

How to Cite

Okada, Y., Kamata, M., Hayashi, K., Sugiura, K., & Tada, Y. (2025). Effectiveness and Safety of Spesolimab in Patients with Generalized Pustular Psoriasis: A Single-centre Retrospective Study. Acta Dermato-Venereologica, 105, adv42879. https://doi.org/10.2340/actadv.v105.42879

Issue

Vol. 105 (2025)

Section

Research letter

Categories

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Copyright (c) 2025 Yoshiki Okada, Masahiro Kamata, Kotaro Hayashi, Kazumitsu Sugiura, Yayoi Tada

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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