Multiple Erythematous Oedematous Plaques on the Neck of a 68-year-old Man: A Quiz

Authors

  • Phanitanun Phusanawiwat Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • Patcharawadee Thongkumkoon Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • Siri Chiewchanvit Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • Chatree Chai-Adisaksopha Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • Mati Chuamanochan Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

DOI:

https://doi.org/10.2340/actadv.v105.43241

Keywords:

VEXAS, Sweet disease, Acute Febrile Neutrophilic Dermatosis

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References

Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, et al. Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease. N Engl J Med 2020; 383: 2628–2638. DOI: https://doi.org/10.1056/NEJMoa2026834

Zhang Y, Dong X, Wang H. VEXAS syndrome. Glob Med Genet 2023; 10: 133–143. DOI: https://doi.org/10.1055/s-0043-1770958

Nicholson LT, Cowen EW, Beck D, Ferrada M, Madigan LM. VEXAS syndrome—diagnostic clues for the dermatologist and gaps in our current understanding: a narrative review. JID Innov 2024; 4: 100242. DOI: https://doi.org/10.1016/j.xjidi.2023.100242

Saad AJ, Patil MK, Cruz N, Lam CS, O’Brien C, Nambudiri VE. VEXAS syndrome: a review of cutaneous findings and treatments in an emerging autoinflammatory disease. Exp Dermatol 2024; 33: e15050. DOI: https://doi.org/10.1111/exd.15050

Hines AS, Mohandesi NA, Lehman JS, Koster MJ, Cantwell HM, Alavi A, et al. Cutaneous involvement in VEXAS syndrome: clinical and histopathologic findings. Int J Dermatol 2023; 62: 938–945. DOI: https://doi.org/10.1111/ijd.16635

Georgin-Lavialle S, Terrier B, Guedon A, Heiblig M, Comont T, Lazaro E, et al. Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients. Br J Dermatol 2022; 186: 564–574. DOI: https://doi.org/10.1136/annrheumdis-2022-eular.992

Al-Hakim A, Savic S. An update on VEXAS syndrome. Expert Rev Clin Immunol 2023; 19: 203–215. DOI: https://doi.org/10.1080/1744666X.2023.2157262

Zakine E, Schell B, Battistella M, Vignon-Pennamen MD, Chasset F, Mahévas T, et al. UBA1 variations in neutrophilic dermatosis skin lesions of patients with VEXAS syndrome. JAMA Dermatol 2021; 157: 1349–1354. DOI: https://doi.org/10.1001/jamadermatol.2021.3344

Heiblig M, Patel BA, Groarke EM, Bourbon E, Sujobert P, editors. Toward a pathophysiology-inspired treatment of VEXAS syndrome. Semin Hematol 2021; 58: 200–206. DOI: https://doi.org/10.1053/j.seminhematol.2021.09.001

Published

2025-07-10

How to Cite

Phanitanun Phusanawiwat, Thongkumkoon, P., Chiewchanvit, S., Chai-Adisaksopha, C., & Chuamanochan, M. (2025). Multiple Erythematous Oedematous Plaques on the Neck of a 68-year-old Man: A Quiz. Acta Dermato-Venereologica, 105, adv43241. https://doi.org/10.2340/actadv.v105.43241