Real–world Experience with JAK Inhibitors and Dupilumab in Dystrophic Epidermolysis Bullosa: A Case Report and Literature Review

Authors

  • Shihua Ling Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China; Shantou University Medical College, Shantou, China
  • Xia Dou Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China

DOI:

https://doi.org/10.2340/actadv.v105.43588

Keywords:

dystrophic epidermolysis bullosa, JAK inhibitors, Dupilumab

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References

Papanikolaou M, Onoufriadis A, Mellerio JE, Nattkemper LA, Yosipovitch G, Steinhoff M, et al. Prevalence, pathophysiology and management of itch in epidermolysis bullosa. Br J Dermatol 2021; 184: 816–825.

https://doi.org/10.1111/bjd.19496 DOI: https://doi.org/10.1111/bjd.19496

Snauwaert JJ, Yuen WY, Jonkman MF, Moons P, Naulaers G, Morren MA. Burden of itch in epidermolysis bullosa. Br J Dermatol 2014; 171: 73–78.

https://doi.org/10.1111/bjd.12885 DOI: https://doi.org/10.1111/bjd.12885

Aala WJF, Hou PC, Hong YK, Lin YC, Lee YR, Tu WT, et al. Dominant dystrophic epidermolysis bullosa is associated with glycolytically active GATA3+ T helper 2 cells which may contribute to pruritus in lesional skin. Br J

Dermatol 2024; 191: 252–260.

https://doi.org/10.1093/bjd/ljae110 DOI: https://doi.org/10.1093/bjd/ljae110

Hou PC, Aala W Jr, Tu WT, McGrath JA, Hsu CK. Real-world experience of using dupilumab and JAK inhibitors to

manage pruritus in epidermolysis bullosa pruriginosa.

Skin Health Dis 2024; 4: e445.

https://doi.org/10.1002/ski2.445 DOI: https://doi.org/10.1002/ski2.445

Kwon IJ, Kim SE, Kim SC, Lee SE. Efficacy of oral JAK1 or JAK1/2 inhibitor for treating refractory pruritus in dystrophic epidermolysis bullosa: a retrospective case series. J Dermatol 2024; 51: 441–447.

https://doi.org/10.1111/1346-8138.17079 DOI: https://doi.org/10.1111/1346-8138.17079

Additional Files

Published

2025-05-27

How to Cite

Ling, S., & Dou, X. (2025). Real–world Experience with JAK Inhibitors and Dupilumab in Dystrophic Epidermolysis Bullosa: A Case Report and Literature Review. Acta Dermato-Venereologica, 105, adv43588. https://doi.org/10.2340/actadv.v105.43588