Comparison of Adjuvant and Salvage Therapy with Immune Checkpoint Inhibitors in Head and Neck Mucosal Melanoma Treated with Proton Beam Therapy: A Retrospective Cohort Study

Authors

  • Ken Horisaki Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Shusuke Yoshikawa Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan
  • Wataru Omata Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan
  • Arata Tsutsumida Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan
  • Yoshio Kiyohara Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan

DOI:

https://doi.org/10.2340/actadv.v105.43602

Keywords:

mucosal, melanoma, proton therapy, immne checkpoint inhibitors, adjuvant

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References

Fuji H, Yoshikawa S, Kasami M, Murayama S, Onitsuka T, Kashiwagi H, et al. High-dose proton beam therapy for sinonasal mucosal malignant melanoma. Radiat Oncol 2014; 9: 162. DOI: https://doi.org/10.1186/1748-717X-9-162

Jacques SK, McKeown J, Grover P, Johnson DB, Zaremba A, Dimitriou F, et al. Outcomes of patients with resected stage III/IV acral or mucosal melanoma, treated with adjuvant anti-PD-1 based therapy. Eur J Cancer 2024; 199: 113563. DOI: https://doi.org/10.1016/j.ejca.2024.113563

Lian B, Tian H, Si L, Chi Z, Sheng X, Wang X, et al. Temozolomide plus cisplatin versus toripalimab (anti-PD-1) as adjuvant therapy in resected mucosal melanoma. J Clin Oncol 2023; 41: 9508. DOI: https://doi.org/10.1200/JCO.2023.41.16_suppl.9508

Mizoguchi N, Kano K, Okuda T, Koge H, Shima S, Tsuchida K, et al. Adjuvant therapy with immune checkpoint inhibitors after carbon ion radiotherapy for mucosal melanoma of the head and neck: a case-control study. Cancers (Basel) 2024; 16: 2625. DOI: https://doi.org/10.3390/cancers16152625

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Published

2025-07-08

How to Cite

Horisaki, K., Yoshikawa, S., Omata, W., Tsutsumida, A., & Kiyohara, Y. (2025). Comparison of Adjuvant and Salvage Therapy with Immune Checkpoint Inhibitors in Head and Neck Mucosal Melanoma Treated with Proton Beam Therapy: A Retrospective Cohort Study. Acta Dermato-Venereologica, 105, adv43602. https://doi.org/10.2340/actadv.v105.43602

Issue

Vol. 105 (2025)

Section

Research letter

Categories

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Copyright (c) 2025 Ken Horisaki, Shusuke Yoshikawa, Wataru Omata, Arata Tsutsumida, Yoshio Kiyohara

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