Combination of Omalizumab and Dupilumab for the Treatment of Severe Bullous Pemphigoid: a Series of 6 Cases

Authors

  • Romain Boisseau Department of Dermatology, Limoges University Hospital Dupuytren, France
  • Lea Scaramuzzino Department of Dermatology, Limoges University Hospital Dupuytren, France
  • Philippe Bernard Department of Dermatology, Limoges University Hospital Dupuytren, France
  • Christophe Bedane Department of Dermatology, Limoges University Hospital Dupuytren, France
  • Salome Fourmond Department of Dermatology, Limoges University Hospital Dupuytren, France

DOI:

https://doi.org/10.2340/actadv.v105.43637

Keywords:

bullous pemphigoid, biotherapy, Biologics, Dupilumab, omalizumab

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References

Akbarialiabad H, Schmidt E, Patsatsi A, Lim YL, Mosam A, Tasanen K, et al. Bullous pemphigoid. Nat Rev Dis Primers 2025; 11: 12. DOI: https://doi.org/10.1038/s41572-025-00595-5

Borradori L, Van Beek N, Feliciani C, Tedbirt B, Antiga E, Bergman R, et al. Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 2022; 36: 1689–1704. DOI: https://doi.org/10.1111/jdv.18220

Kridin K, Bergman R. Mortality in patients with bullous pemphigoid: a retrospective cohort study, systematic review and meta-analysis. Acta Derm Venereol 2019; 99: 72–77. DOI: https://doi.org/10.2340/00015555-2930

Chebani R, Lombart F, Chaby G, Dadban A, Debarbieux S, Viguier MA, et al. Omalizumab in the treatment of bullous pemphigoid resistant to first-line therapy: a French national multicentre retrospective study of 100 patients. Br J Dermatol 2024; 190: 258–265. DOI: https://doi.org/10.1093/bjd/ljad369

Karakioulaki M, Eyerich K, Patsatsi A. Advancements in bullous pemphigoid treatment: a comprehensive pipeline update. Am J Clin Dermatol 2024; 25: 195–212. DOI: https://doi.org/10.1007/s40257-023-00832-1

Vassallo C, Somenzi A, De Amici M, Barruscotti S, Brazzelli V. Omalizumab as a corticosteroid-sparing agent in the treatment of bullous pemphigoid. Dermatol Ther 2022; 35: e15946. DOI: https://doi.org/10.1111/dth.15946

Harb H, Chatila TA. Mechanisms of dupilumab. Clin Exp Allergy 2020; 50: 5–14. DOI: https://doi.org/10.1111/cea.13491

Zhao L, Wang Q, Liang G, Zhou Y, Yiu N, Yang B, et al. Evaluation of dupilumab in patients with bullous pemphigoid. JAMA Dermatol 2023; 159: 953–960. DOI: https://doi.org/10.1001/jamadermatol.2023.2428

Planella-Fontanillas N, Bosch-Amate X, Jiménez Antón A, Moreno-Vílchez C, Guerrero MG, Blanes Martínez MDM, et al. Real-world evaluation of the effectiveness and safety of dupilumab in bullous pemphigoid: an ambispective multicentre case series. Br J Dermatol 2025; 192: 501–509. DOI: https://doi.org/10.1093/bjd/ljae403

Seyed Jafari SM, Feldmeyer L, Bossart S, Simon D, Schlapbach C, Borradori L. Case Report: Combination of omalizumab and dupilumab for recalcitrant bullous pemphigoid. Front Immunol 2021; 11: 611549. DOI: https://doi.org/10.3389/fimmu.2020.611549

Published

2025-10-28

How to Cite

Boisseau, R., Scaramuzzino, L., Bernard, P., Bedane, C., & Fourmond, S. (2025). Combination of Omalizumab and Dupilumab for the Treatment of Severe Bullous Pemphigoid: a Series of 6 Cases. Acta Dermato-Venereologica, 105, adv43637. https://doi.org/10.2340/actadv.v105.43637