Strategies for Managing Suboptimal Response to JAK Inhibitors in Alopecia Areata

Authors

  • S. Morteza Seyed Jafari Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland
  • Pierre A. de Viragh Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland

DOI:

https://doi.org/10.2340/actadv.v105.44193

Keywords:

Alopecia areata, JAK inhibitors, clinical effectiveness, management

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References

Kwon O, Senna MM, Sinclair R, Ito T, Dutronc Y, Lin CY, et al. Efficacy and safety of baricitinib in patients with severe alopecia areata over 52 weeks of continuous therapy in two phase III trials (BRAVE-AA1 and BRAVE-AA2). Am J Clin Dermatol 2023; 24: 443–451. DOI: https://doi.org/10.1007/s40257-023-00764-w

King B, Shapiro J, Ohyama M, Egeberg A, Piraccini BM, Craiglow B, et al. When to expect scalp hair regrowth during treatment of severe alopecia areata with baricitinib: insights from trajectories analyses of patients enrolled in two phase III trials. Br J Dermatol 2023; 189: 666–673. DOI: https://doi.org/10.1093/bjd/ljad253

Senna M, Mostaghimi A, Ohyama M, Sinclair R, Dutronc Y, Wu WS, et al. Long-term efficacy and safety of baricitinib in patients with severe alopecia areata: 104-week results from BRAVE-AA1 and BRAVE-AA2. J Eur Acad Dermatol Venereol 2024; 38: 583–593. DOI: https://doi.org/10.1111/jdv.19665

Majewski M, Gardaś K, Waśkiel-Burnat A, Ordak M, Rudnicka L. The role of minoxidil in treatment of alopecia areata: a systematic review and meta-analysis. J Clin Med 2024;13: 7712. DOI: https://doi.org/10.3390/jcm13247712

Rudnicka L, Arenbergerova M, Grimalt R, Ioannides D, Katoulis AC, Lazaridou E, et al. European expert consensus statement on the systemic treatment of alopecia areata. J Eur Acad Dermatol Venereol 2024; 38: 687–694. DOI: https://doi.org/10.1111/jdv.19768

Valido K, Kalil L, Peterson D, King B. Combination oral minoxidil and baricitinib treatment of alopecia areata. J Am Acad Dermatol 2025; May 16 [Online ahead of print]. DOI: https://doi.org/10.1016/j.jaad.2025.05.1393

Thompson JM, Mirza MA, Park MK, Qureshi AA, Cho E. The role of micronutrients in alopecia areata: a review. Am J Clin Dermatol 2017; 18: 663–679. DOI: https://doi.org/10.1007/s40257-017-0285-x

Kazmi A, Moussa A, Bokhari L, Bhoyrul B, Joseph S, Chitreddy V, et al. Switching between tofacitinib and baricitinib in alopecia areata: a review of clinical response. J Am Acad Dermatol 2023; 89: 1248–1250. DOI: https://doi.org/10.1016/j.jaad.2023.03.041

Published

2025-08-12

How to Cite

Seyed Jafari, S. M., & de Viragh, P. A. (2025). Strategies for Managing Suboptimal Response to JAK Inhibitors in Alopecia Areata. Acta Dermato-Venereologica, 105, adv44193. https://doi.org/10.2340/actadv.v105.44193