Early Recurrence of Nodular Basal Cell Carcinoma Despite Negative Margins: A Case Report

Authors

  • Yuto Yamamura Department of Dermatology, Kindai University Hospital, Osaka, Japan
  • Kazuyasu Fujii Department of Dermatology, Kindai University Hospital, Osaka, Japan
  • Chisa Nakashima Department of Dermatology, Kindai University Hospital, Osaka, Japan
  • Shunya Usui Department of Dermatology, Kindai University Hospital, Osaka, Japan
  • Atsushi Otsuka Department of Dermatology, Kindai University Hospital, Osaka, Japan

DOI:

https://doi.org/10.2340/actadv.v105.44195

Keywords:

Basal cell carcinoma, recurrence, surgical margins, histological subtype, nodular

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References

Bartoš V, Pock L, Hercogová J, Mandys V. Recurrent basal cell carcinoma: a clinicopathological study and evaluation of histomorphological findings in primary and recurrent lesions. Acta Dermatovenerol Alp Panonica Adriat 2011; 20: 67–75.

Crowson AN. Basal cell carcinoma: biology, morphology and clinical implications. Mod Pathol 2006; 19: S127–S147. DOI: https://doi.org/10.1038/modpathol.3800512

Di Maria A, Foresta V, Matarazzo G, Rega D, Schicchi L, Cantelli M, et al. Recurrence of basal cell carcinoma treated with surgical excision and histopathological analysis with frozen section technique with complete margin control (CMC-FS): a 15-year experience of a reference center. Cancers (Basel) 2023; 15: 2359. DOI: https://doi.org/10.3390/cancers15153840

Iurilli M, Cazzato V, Ramella V, Papa G. Exploring the role of surgical margins and reoperation in basal cell carcinoma recurrence: a study of 3036 cases. Arch Dermatol Res 2025; 317: 604–612. DOI: https://doi.org/10.1007/s00403-025-04084-3

Sexton M, Jones DB, Maloney ME. Histologic pattern analysis of basal cell carcinoma: study of a series of 1039 consecutive neoplasms. J Am Acad Dermatol 1990; 23: 1118–1126. DOI: https://doi.org/10.1016/0190-9622(90)70344-H

Rezac L, Wallis L, Black WH, Pearlman RL. Evaluation of a teledermatology postoperative follow-up model after Mohs micrographic surgery. Dermatol Surg 2024; 50: 587–588. DOI: https://doi.org/10.1097/DSS.0000000000004126

Lang PG Jr, Maize JC. Histologic evolution of recurrent basal cell carcinoma and treatment implications. J Am Acad Dermatol 1986; 14: 186–196. DOI: https://doi.org/10.1016/S0190-9622(86)70020-0

Published

2025-07-25

How to Cite

Yamamura, Y., Fujii, K., Nakashima, C., Usui, S., & Otsuka, A. (2025). Early Recurrence of Nodular Basal Cell Carcinoma Despite Negative Margins: A Case Report. Acta Dermato-Venereologica, 105, adv44195. https://doi.org/10.2340/actadv.v105.44195

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Short Communication

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