Neoadjuvant Hedgehog Inhibitors for Locally Advanced Basal Cell Carcinoma: Insights from Two Real-world Cases
DOI:
https://doi.org/10.2340/actadv.v105.44212Keywords:
Basal Cell Carcinoma (BCC), Locally advanced basal cell carcinoma, neoadjuvant, sonidegib, Vismodegib, Radiotherapy, hedgehog inhibitorsDownloads
References
Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, et al. EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E: European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Eur J Cancer 2023; 192: 113254. DOI: https://doi.org/10.1016/j.ejca.2023.113254
Cebolla-Verdugo M, Llamas-Segura C, Velasco-Amador JP, Almazán-Fernández FM, Ruiz-Villaverde R. Understanding and managing locally advanced basal cell carcinoma: insights into pathogenesis, therapeutic strategies, and the role of hedgehog pathway inhibitors. Ital J Dermatol Venerol 2024; 159: 530–542. DOI: https://doi.org/10.23736/S2784-8671.24.07993-3
Bertrand N, Guerreschi P, Basset-Seguin N, Saiag P, Dupuy A, Dalac-Rat S, et al. Vismodegib in neoadjuvant treatment of locally advanced basal cell carcinoma: first results of a multicenter, open-label, phase 2 trial (VISMONEO study): neoadjuvant vismodegib in locally advanced basal cell -carcinoma. EClinicalMedicine 2021; 35: 100844. DOI: https://doi.org/10.1016/j.eclinm.2021.100844
Jabbehdari S, Veluvolu M, Kornhauser T, Jennings TA, Pemberton JD. Vismodegib as an adjuvant treatment for periorbital basal cell carcinoma: a case report and review of literature. Ann Transl Med 2024; 12: 54. DOI: https://doi.org/10.21037/atm-23-1589
Herms F, Baroudjian B, Delyon J, Laly P, Tetu P, Lebbe C, et al. Sonidegib in the treatment of locally advanced basal cell carcinoma: a retrospective study. Acta Derm Venereol 2022; 102: adv00740. DOI: https://doi.org/10.2340/actadv.v102.1995
Paradisi A, Piccerillo A, Bocchino E, Cappilli S, Ricci C, Di Stefani A, et al. Surgery after sonidegib treatment achieves complete response in locally advanced basal cell carcinoma of the face. J Dermatol 2024; 51: 106–109. DOI: https://doi.org/10.1111/1346-8138.16970
Harvima, RJ, Ilves T, Turunen H, Nuutinen H. Treatment of multiple locally advanced basal cell carcinomas by sonidegib combined with surgery and radiation therapy: a case report. J Clin Med Re: AJCMR-193, 2025.
Dummer R, Ascierto PA, Basset-Seguin N, Dréno B, Garbe C, Gutzmer R, et al. Sonidegib and vismodegib in the treatment of patients with locally advanced basal cell carcinoma: a joint expert opinion. J Eur Acad Dermatol Venereol 2020; 34: 1944–1956. DOI: https://doi.org/10.1111/jdv.16230
Herms F, Djermane M, Beylot-Barry M, Chaffaut C, Dalac S, Dereure, et al. Locally advanced basal cell carcinoma in real life: analysis of a cohort of 452 patients treated with systemic therapy from the CARADERM database. EJC Skin Cancer 2025; 100729. DOI: https://doi.org/10.1016/j.ejcskn.2025.100729
Migden MR, Farberg AS, Spencer J, Kiecker F, Guminski A, Gebauer K, et al. Sonidegib reduced tumor burden in patients with advanced basal cell carcinoma in the BOLT trial: long-term analysis results. EJC Skin Cancer 2024; 2: 100267. DOI: https://doi.org/10.1016/j.ejcskn.2024.100267
ClinicalTrials.Gov. A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma (SONIB). Available from: https://clinicaltrials.gov/study/NCT03534947
Gutzmer R, Leiter U, Mohr P, Kähler KC, Ascierto PA, -Scalvenzi M, et al. Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma. BMC Cancer 2024; 24: 1401. DOI: https://doi.org/10.1186/s12885-024-13101-z
Weissman JP, Samlowski W, Meoz R. Hedgehog inhibitor induction with addition of concurrent superficial radiotherapy in patients with locally advanced basal cell carcinoma: a case series. Oncologist 2021; 26: e2247–e2253. DOI: https://doi.org/10.1002/onco.13959
Barker CA, Dufault S, Arron ST, Ho AL, Algazi AP, Dunn La, et al. Phase II, single-arm trial of induction and concurrent vismodegib with curative-intent radiation therapy for locally advanced, unresectable basal cell carcinoma. J Clin Oncol 2024; 42: 2327–2335. DOI: https://doi.org/10.1200/JCO.23.01708
Boileau M, Dubois M, Pruvot C, Desmedt E, Templier C, Meyer N, et al. Sequential combination of sonic hedgehog inhibitors followed by consolidation radiotherapy in locally advanced basal cell carcinoma. Clin Exp Dermatol 2024; 49: 1024–1028. DOI: https://doi.org/10.1093/ced/llae068
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Copyright (c) 2025 Paolo Antonetti, Ettore Lupi, Irene Tucceri Cimini, Maria Esposito, Maria Concetta Fargnoli
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