Successful Treatment of Comorbid SAPHO Syndrome and Hidradenitis Suppurativa with Upadacitinib

Authors

  • Deepika Narayanan Center for Clinical Studies, Houston, TX, USA
  • Tiffaney Tran Department of Dermatology, The University of Texas Health Science Center at Houston, Houston, TX, USA
  • Valeria Duque-Clavijo Universidad de los Andes, Bogotá, Colombia
  • Hung Q. Doan Department of Dermatology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
  • Stephen K. Tyring Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, The University of Texas Health Science Center at Houston, Houston, TX, USA

DOI:

https://doi.org/10.2340/actadv.v105.44265

Keywords:

SAPHO Syndrome, Upadacitinib, Hidradenitis suppurativa, Janus Kinase Inhibitors, autoinflammatory diseases

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References

Ferraioli M, Levani J, De Luca R, Matucci-Cerinic C, Gattorno M, Guiducci S, et al. What is new and what is next for SAPHO syndrome management: a narrative review. J Clin Med 2025; 14: 1366. DOI: https://doi.org/10.3390/jcm14041366

Sabat R, Jemec GBE, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Prim 2020; 6: 18. DOI: https://doi.org/10.1038/s41572-020-0149-1

Benhamou C, Chamot AM, Kahn MF. Le syndrome synovite–acné–pustulose–hyperostose–ostéite (SAPHO). Ann Dermatol Venereol 1988; 115: 613–618.

Chamot AM, Benhamou CL, Kahn MF, Beraneck L, Kaplan G, Prost A. Le syndrome acné pustulose hyperostose ostéite (SAPHO). Résultats d’une enquête nationale. 85 observations. Rev Rhum Mal Osteoartic 1987; 53: 187–196.

Maronese CA, Moltrasio C, Marzano AV. Hidradenitis suppurativa-related autoinflammatory syndromes: an updated review on the clinics, genetics, and treatment of pyoderma gangrenosum, acne and suppurative hidradenitis (PASH), pyogenic arthritis, pyoderma gangrenosum, acne and suppurative hidradenitis (PAPASH), synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO), and rarer forms. Dermatol Clin 2024; 42: 247–265. DOI: https://doi.org/10.1016/j.det.2023.12.004

Firinu D, Barca MP, Lorrai MM, Perra S, Cabras S, Muggianu E, et al. TH17 cells are increased in the peripheral blood of patients with SAPHO syndrome. Autoimmunity 2014; 47: 389–394. DOI: https://doi.org/10.3109/08916934.2014.906582

Yue Q, Ma M, Liu S, Wu Y, Li C. JAKi: can it be used to treat SAPHO syndrome? Int J Rheum Dis 2024; 27: e14930. DOI: https://doi.org/10.1111/1756-185X.14930

Ma M, Lu S, Hou X, Li C. Novel JAK-1 inhibitor upadacitinib as a possible treatment for refractory SAPHO syndrome: a case report. Int J Rheum Dis 2023; 26: 2335–2337. DOI: https://doi.org/10.1111/1756-185X.14774

Tan IJ, Nguyen HN, Wolfe SM, Agarwal P, Cohen BA. Targeted biologic therapies for hidradenitis suppurativa. Int J Mol Sci 2025; 26: 8887. DOI: https://doi.org/10.3390/ijms26188887

Duggan S, Keam SJ. Upadacitinib: first approval. Drugs 2019; 79: 1819–1828. DOI: https://doi.org/10.1007/s40265-019-01211-z

Published

2025-12-16

How to Cite

Narayanan, D., Tran, T., Duque-Clavijo, V., Doan, H. Q., & Tyring, S. K. (2025). Successful Treatment of Comorbid SAPHO Syndrome and Hidradenitis Suppurativa with Upadacitinib. Acta Dermato-Venereologica, 105, adv44265. https://doi.org/10.2340/actadv.v105.44265