The Absence of Recent Systemic Therapy can be a Significant Risk Factor for Nemolizumab-associated Cutaneous Adverse Events in Patients with Prurigo Nodularis: A Single-centre Retrospective Study

Authors

  • Yoshihito Mima Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan
  • Masako Yamamoto Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan
  • Ken Iozumi Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan

DOI:

https://doi.org/10.2340/actadv.v105.44310

Keywords:

Prurigo nodularis, Nemolizumab, systemic therapy, cutaneous adverse events, Th2

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References

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Kwatra SG, Yosipovitch G, Legat FJ, Reich A, Paul C, Simon D, et al. Phase 3 trial of nemolizumab in patients with prurigo nodularis. N Engl J Med 2023; 389: 1579–1589. DOI: https://doi.org/10.1056/NEJMoa2301333

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Mima Y, Yamamoto M, Iozumi K. Cutaneous adverse events following nemolizumab administration: a review. J Clin Med 2025; 14: 3026. DOI: https://doi.org/10.3390/jcm14093026

Mima Y, Yamamoto M, Iozumi K. Transient elevation of eosinophil and thymus and activation-regulated chemokine levels associated with cutaneous adverse events due to nemolizumab: a case report. Dermatitis 2025 Sep 12. [Online ahead of print]. DOI: https://doi.org/10.1177/17103568251380242

Mima Y, Ohtsuka T. A Case of erythema multiforme following the administration of nemolizumab. Cureus 2025; 17: e79070. DOI: https://doi.org/10.7759/cureus.79070

Mima Y, Yamamoto M, Iozumi K. Four cases of prurigo nodularis requiring nemolizumab due to persistent pruritus or lesions after dupilumab treatment. Acta Derm Venereol 2025; 105: adv43419. DOI: https://doi.org/10.2340/actadv.v105.43419

Mima Y, Yamamoto M, Iozumi K. Effectiveness of nemolizumab in improving dialysis-associated pruritus refractory to difelikefalin: a case report. Cureus 2025; 17: e83367. DOI: https://doi.org/10.7759/cureus.83367

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Published

2025-10-23

How to Cite

Mima, Y., Yamamoto, M., & Iozumi, K. (2025). The Absence of Recent Systemic Therapy can be a Significant Risk Factor for Nemolizumab-associated Cutaneous Adverse Events in Patients with Prurigo Nodularis: A Single-centre Retrospective Study. Acta Dermato-Venereologica, 105, adv44310. https://doi.org/10.2340/actadv.v105.44310