Intralesional Corticosteroid Versus Cryotherapy for Alopecia Areata: A Systematic Review and Meta-analysis

Authors

  • Yu-Cheng Liu Department of General Medicine, Taipei Medical University Shuang Ho Hospital, New Taipei, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
  • Kai-Wen Chuang Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan
  • Hua-Ching Chang Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan; Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan https://orcid.org/0000-0003-3608-1394

DOI:

https://doi.org/10.2340/actadv.v105.44435

Keywords:

alopecia areata, cryotherapy, intralesional corticosteroid, triamcinolone

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References

Strazzulla LC, Wang EHC, Avila L, Lo Sicco K, Brinster N, Christiano AM, et al. Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis. J Am Acad Dermatol 2018; 78: 1–12. DOI: https://doi.org/10.1016/j.jaad.2017.04.1141

Yang CC, Chen CC, Lin TK, Lin MH, Lin SJ, Chi CC, et al. Taiwanese Dermatological Association consensus on the diagnosis and management of alopecia areata. Dermatologica Sinica 2025; 43: 26–35. DOI: https://doi.org/10.4103/ds.DS-D-24-00188

Lee H, Lee JW, Park S, Park H, Kim GH, Kwon O. Comparative analysis of temperature-controlled cryotherapy versus intralesional triamcinolone acetonide injection for alopecia areata: an intrasubject split-lesion pilot study. J Eur Acad Dermatol Venereol 2025; 39: e505–e507. DOI: https://doi.org/10.1111/jdv.20464

Ban HZ, Qi HY, Feng XQ. Observation on the efficacy of three methods for treating alopecia areata. J North Pharmacy 2014; 11: 51–52.

Amirnia M, Mahmoudi SS, Karkon-Shayan F, Alikhah H, Piri R, Naghavi-Behzad M, et al. Comparative study of intralesional steroid injection and cryotherapy in alopecia areata. Niger Med J 2015; 56: 249–252. DOI: https://doi.org/10.4103/0300-1652.165034

El Sayed MH, Ibrahim NE, Afify AA. Superficial cryotherapy versus intralesional corticosteroids injection in alopecia areata: a trichoscopic comparative study. Int J Trichology 2022; 14: 8–13. DOI: https://doi.org/10.4103/ijt.ijt_130_20

Mohammed AIA, Farag AS, Hafiz HS. Superficial cryotherapy versus intralesional corticosteroid injection in alopecia areata: a comparative clinical and dermoscopic study. Egypt J Hosp Med 2022; 86: 211–217. DOI: https://doi.org/10.21608/ejhm.2022.211050

Sardana S, Goyal T, Kushwaha P, Jha P. A prospective study to compare the efficacy of cryotherapy versus intralesional steroid in alopecia areata. J Cutan Aesthet Surg 2022; 15: 175–178. DOI: https://doi.org/10.4103/JCAS.JCAS_166_20

Published

2025-09-04

How to Cite

Liu, Y.-C., Chuang, K.-W., & Chang, H.-C. (2025). Intralesional Corticosteroid Versus Cryotherapy for Alopecia Areata: A Systematic Review and Meta-analysis. Acta Dermato-Venereologica, 105, adv44435. https://doi.org/10.2340/actadv.v105.44435

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Research letter

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