Effectiveness and Safety of Delgocitinib Cream in Pustulosis Palmoplantaris: A Case Series

Authors

  • Nikolai Loft Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Denmark
  • Claus Zachariae Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark
  • Mette Gyldenløve Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark
  • Farzad Alinaghi Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Denmark
  • Diljit Kaur-Knudsen
  • Lone Skov Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark

DOI:

https://doi.org/10.2340/actadv.v105.44511

Keywords:

Psoriasis, Pustolosis palmoplantaris, palmoplantar, JAK inhibitor

Downloads

Download data is not yet available.

References

Misiak-Galazka M, Zozula J, Rudnicka L. Palmoplantar pustulosis: recent advances in etiopathogenesis and emerging treatments. Am J Clin Dermatol 2020; 21: 355–370. DOI: https://doi.org/10.1007/s40257-020-00503-5

Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Köks S, et al. European consensus statement on phenotypes of pustular psoriasis. J Eur Acad Dermatol Venereol 2017; 31: 1792–1799. DOI: https://doi.org/10.1111/jdv.14386

Heidemeyer K, May Lee M, Cazzaniga S, Yawalkar N, Naldi L. Palmoplantar pustulosis: a systematic review of risk factors and therapies. Psoriasis 2023; 13: 33–58. DOI: https://doi.org/10.2147/PTT.S400402

Xu Q, Wang X, Yang A, Wei G. Refractory palmoplantar pustulosis successfully treated with JAK inhibitor tofacitinib: a case series. Infect Drug Resist 2023; 16: 5165–5172. DOI: https://doi.org/10.2147/IDR.S421299

Du N, Yang J, Zhang Y, Lv X, Cao L, Min W. Successful treatment of refractory palmoplantar pustulosis by upadacitinib: report of 28 patients. Front Med 2024; 11: 1476793. DOI: https://doi.org/10.3389/fmed.2024.1476793

Rahbar Kooybaran N, Tsianakas A, Assaf K, Mohr J, Wilsmann-Theis D, Mössner R. Response of palmoplantar pustulosis to upadacitinib: a case series of five patients. J Dtsch Dermatol Ges 2023; 21: 1387–1392. DOI: https://doi.org/10.1111/ddg.15176

Gleeson D, Barker JN, Capon F, Pink AE, Woolf RT, Smith CH, et al. Are Janus kinase inhibitors an effective treatment for palmoplantar pustulosis? A critically appraised topic. Br J Dermatol 2023; 188: 471–473. DOI: https://doi.org/10.1093/bjd/ljac130

Bissonnette R, Warren RB, Pinter A, Agner T, Gooderham M, Schuttelaar ML, et al. Efficacy and safety of delgocitinib cream in adults with moderate to severe chronic hand eczema (DELTA 1 and DELTA 2): results from multicentre, randomised, controlled, double-blind, phase 3 trials. Lancet 2024; 404: 461–473. DOI: https://doi.org/10.1093/bjd/ljae266.032

McCluskey D, Benzian-Olsson N, Mahil SK, Hassi NK, Wohnhaas CT, Burden AD, et al. Single-cell analysis implicates T(H)17-to-T(H)2 cell plasticity in the pathogenesis of palmoplantar pustulosis. J Allergy Clin Immunol 2022; 150: 882–893. DOI: https://doi.org/10.1016/j.jaci.2022.04.027

Published

2025-11-11

How to Cite

Loft, N., Zachariae, C., Gyldenløve, M., Alinaghi, F., Kaur-Knudsen, D., & Skov, L. (2025). Effectiveness and Safety of Delgocitinib Cream in Pustulosis Palmoplantaris: A Case Series. Acta Dermato-Venereologica, 105, adv44511. https://doi.org/10.2340/actadv.v105.44511

Issue

Section

Research letter

Categories