Successful Treatment of Subcorneal Pustular Dermatosis with Abrocitinib

Authors

  • Zirui Chen Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
  • Jiahui Zhao Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
  • Hang Li Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China

DOI:

https://doi.org/10.2340/actadv.v105.44512

Keywords:

neutrophilic dermatosis, JAK-inhibitor, treatment

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References

Watts PJ, Khachemoune A. Subcorneal pustular dermatosis: a review of 30 years of progress. Am J Clin Dermatol 2016; 17: 653–671. DOI: https://doi.org/10.1007/s40257-016-0202-8

Tagami H, Iwatsuki K, Iwase Y, Yamada M. Subcorneal pustular dermatosis with vesiculo-bullous eruption: demonstration of subcorneal IgA deposits and a leukocyte chemotactic factor. Br J Dermatol 1983; 109: 581–587. DOI: https://doi.org/10.1111/j.1365-2133.1983.tb07683.x

Grob JJ, Mege JL, Capo C, Jancovicci E, Fournerie JR, Bongrand P, et al. Role of tumor necrosis factor-alpha in Sneddon-Wilkinson subcorneal pustular dermatosis: a model of neutrophil priming in vivo. J Am Acad Dermatol 1991; 25: 944–947. DOI: https://doi.org/10.1016/0190-9622(91)70290-I

Koken Avsar A, Demirci Yildirim T, Sari I. Tofacitinib therapy for severe pyoderma gangrenosum in a patient with enteropathic arthritis: a case-based review. Rheumatol Int 2024 2024; 44: 2227–2237. DOI: https://doi.org/10.1007/s00296-024-05560-1

Schell SL, Cong ZY, Sennett ML, Gettle SL, Longenecker AL, Goldberg SR, et al. Keratinocytes and immune cells in the epidermis are key drivers of inflammation in hidradenitis suppurativa providing a rationale for novel topical therapies. Brit J Dermatol 2023; 188: 407–419. DOI: https://doi.org/10.1093/bjd/ljac096

Grolleau C, Calugareanu A, Demouche S, Nosbaum A, Staumont-Salle D, Aubert H, et al. IL-4/IL-13 inhibitors for atopic dermatitis induce psoriatic rash transcriptionally close to pustular psoriasis. J Invest Dermatol 2023; 143: 711–721 e717. DOI: https://doi.org/10.1016/j.jid.2022.10.015

Hall S, Chew CY, Kovitwanichkanont T, Ip KH, Cahill J, Gin A, et al. Subcorneal pustular dermatosis induced by dupilumab: a novel case. Australas J Dermatol 2024; 65: 74–76. DOI: https://doi.org/10.1111/ajd.14190

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Published

2025-09-01

How to Cite

Chen, Z., Zhao, J., & Li, H. (2025). Successful Treatment of Subcorneal Pustular Dermatosis with Abrocitinib. Acta Dermato-Venereologica, 105, adv44512. https://doi.org/10.2340/actadv.v105.44512

Issue

Vol. 105 (2025)

Section

Research letter

License

Copyright (c) 2025 Zirui Chen, Jiahui Zhao, Hang Li

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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