Can Week 4 PASI Response Serve as an Early Predictor of Apremilast Efficacy in Psoriasis? A Single-Centre Preliminary Study

Authors

  • Seyma Nur Erol Department of Dermatology and Venereology, Ankara Etlik City Hospital, Ankara, Turkey
  • Selda Pelin Kartal Department of Dermatology and Venereology, Ankara Etlik City Hospital, Ankara, Turkey

DOI:

https://doi.org/10.2340/actadv.v105.44624

Keywords:

apremilast, psoriasis, treatment efficacy, PASI Response Rates, clinical decision-making

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References

Papp K, Reich K, Leonardi CL, Kircik L, Chimenti S, Langley RG, et al. Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and safety trial evaluating the effects of apremilast in psoriasis [ESTEEM] 1). J Am Acad Dermatol 2015; 73: 37–49. DOI: https://doi.org/10.1016/j.jaad.2015.03.049

Keating GM. Apremilast: a review in psoriasis and psoriatic arthritis. Drugs 2017; 77: 459–472. DOI: https://doi.org/10.1007/s40265-017-0709-1

Kelly JB 3rd, Foley P, Strober BE. Current and future oral systemic therapies for psoriasis. Dermatol Clin 2015; 33: 91–109. DOI: https://doi.org/10.1016/j.det.2014.09.008

Nash P, Ohson K, Walsh J, Delev N, Nguyen D, Teng L, et al. Early and sustained efficacy with apremilast monotherapy in biological-naïve patients with psoriatic arthritis: a phase IIIB, randomised controlled trial (ACTIVE). Ann Rheum Dis 2018; 77: 690–698. DOI: https://doi.org/10.1136/annrheumdis-2017-211568

Strober B, Alikhan A, Lockshin B, Shi R, Cirulli J, Schafer P. Apremilast mechanism of efficacy in systemic-naive

patients with moderate plaque psoriasis: pharmacodynamic results from the UNVEIL study. J Dermatol Sci 2019; 96: 126–133. DOI: https://doi.org/10.1016/j.jdermsci.2019.09.003

Okubo Y, Takahashi H, Hino R, Endo K, Kikuchi S, Ozeki Y, et al. Efficacy and safety of apremilast in the treatment of patients with mild-to-moderate psoriasis in Japan: results from PROMINENT, a phase 3b, open-label, single-arm study. Dermatol Ther (Heidelb) 2022; 12: 1469–1480. DOI: https://doi.org/10.1007/s13555-022-00747-5

Nast A, Dilleen M, Liyanage W, Aikman L, Szczypa P, Dressler C. Time, Psoriasis Area and Severity Index and Dermatology Life Quality Index of patients with psoriasis who drop out of clinical trials on etanercept because of lack of efficacy: a pooled analysis from 10 clinical trials. Br J Dermatol 2018; 178: 400–405. DOI: https://doi.org/10.1111/bjd.15864

Additional Files

Published

2025-09-16

How to Cite

Erol, S. N., & Kartal, S. P. (2025). Can Week 4 PASI Response Serve as an Early Predictor of Apremilast Efficacy in Psoriasis? A Single-Centre Preliminary Study. Acta Dermato-Venereologica, 105, adv44624. https://doi.org/10.2340/actadv.v105.44624

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Research letter

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