Spesolimab Rapidly Resolved Capillary Leak Syndrome Associated with Generalized Pustular Psoriasis

Authors

  • Yoshiki Okada Department of Dermatology, Teikyo University School of Medicine, Kaga, Itabashi-ku, Tokyo, Japan
  • Masahiro Kamata Department of Dermatology, Teikyo University School of Medicine, Kaga, Itabashi-ku, Tokyo, Japan
  • Kotaro Hayashi Department of Dermatology, Teikyo University School of Medicine, Kaga, Itabashi-ku, Tokyo, Japan
  • Kazumitsu Sugiura Department of Dermatology, Fujita Health University, Toyoake, Japan
  • Yayoi Tada Department of Dermatology, Teikyo University School of Medicine, Kaga, Itabashi-ku, Tokyo, Japan

DOI:

https://doi.org/10.2340/actadv.v105.adv-2025-0012

Keywords:

spesolimab, generalized pustular psoriasis, capillary leak syndrome

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References

Handfield-Jones SE, Garvey M, McGibbon DH, Black MM. Capillary leak syndrome in generalized pustular psoriasis. Br J Dermatol 1992; 127: 64. DOI: https://doi.org/10.1111/j.1365-2133.1992.tb14833.x

Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, et al. Japanese guidelines for the management and treatment of generalized pustular psoriasis: the new pathogenesis and treatment of GPP. J Dermatol 2018; 45: 1235–1270. DOI: https://doi.org/10.1111/1346-8138.14523

Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, et al. Trial of spesolimab for generalized pustular psoriasis. N Engl J Med 2021; 385: 2431–2440. DOI: https://doi.org/10.1056/NEJMoa2111563

Morita A, Tsai TF, Yee EYW, Okubo Y, Imafuku S, Zheng M, et al. Efficacy and safety of spesolimab in Asian patients with a generalized pustular psoriasis flare: results from the randomized, double-blind, placebo-controlled Effisayil™ 1 study. J Dermatol 2023; 50: 183–194. DOI: https://doi.org/10.1111/1346-8138.16609

Okada Y, Kamata M, Hayashi K, Sugiura K, Tada Y. Effectiveness and safety of spesolimab in patients with generalized pustular psoriasis: a single-centre retrospective study. Acta Derm Venereol 2025; 105: adv42879. DOI: https://doi.org/10.2340/actadv.v105.42879

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Published

2025-12-11

How to Cite

Okada, Y., Kamata, M., Hayashi, K., Sugiura, K., & Tada, Y. (2025). Spesolimab Rapidly Resolved Capillary Leak Syndrome Associated with Generalized Pustular Psoriasis. Acta Dermato-Venereologica, 105, adv–2025. https://doi.org/10.2340/actadv.v105.adv-2025-0012

Issue

Vol. 105 (2025)

Section

Short Communication

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