Primary Cutaneous Adult T-cell Leukaemia/Lymphoma Presenting as Generalized Purpura

Authors

  • Kazuki Watanabe Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
  • Ken Natsuga Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan https://orcid.org/0000-0003-3865-6366
  • Masahiro Onozawa Department of Hematology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
  • Toshiro Kikuchi Kikuchi Dermatology Clinic, Sapporo, Japan
  • Hideyuki Ujiie Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0119

Keywords:

Cutaneous T-cell lymphoma, HTLV-1, purpura

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References

Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphoma. Br J Haematol 1991; 79: 428–437. DOI: https://doi.org/10.1111/j.1365-2141.1991.tb08051.x

Amano M, Kurokawa M, Ogata K, Itoh H, Kataoka H, Setoyama M. New entity, definition and diagnostic criteria of cutaneous adult T-cell leukemia/lymphoma: human T-lymphotropic virus type 1 proviral DNA load can distinguish between cutaneous and smoldering types. J Dermatol 2008; 35: 270–275. DOI: https://doi.org/10.1111/j.1346-8138.2008.00465.x

Sawada Y, Hino R, Hama K, Ohmori S, Fueki H, Yamada S, et al. Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia/lymphoma. Blood 2011; 117: 3961–3967. DOI: https://doi.org/10.1182/blood-2010-11-316794

Kao DE, Chen CP, Fang KT, Hsu YH, Hung SJ. A rare presentation of adult T-cell leukemia/lymphoma with generalized cutaneous purpuric lesions. Dermatol Sinica 2015; 33: 234–238. DOI: https://doi.org/10.1016/j.dsi.2015.02.003

Oliveira PD, Torres ISM, Oliveira RF, Bittencourt AL. Acute adult T-cell leukemia/lymphoma (ATL) presenting with cutaneous purpuric lesions: a rare presentation. Acta Oncol 2011; 50: 595–597. DOI: https://doi.org/10.3109/0284186X.2010.534815

Okada J, Imafuku S, Tsujita J, Moroi Y, Urabe K, Furue M. Case of adult T-cell leukemia/lymphoma manifesting marked purpura. J Dermatol 2007; 34: 782–785. DOI: https://doi.org/10.1111/j.1346-8138.2007.00384.x

Tabata R, Tabata C, Namiuchi S, Terada M, Yasumizu R, Okamoto T, et al. Adult T-cell lymphoma mimicking henochschönlein purpura. Mod Rheumatol 2007; 17: 57–62. DOI: https://doi.org/10.1007/s10165-006-0534-y

Shimauchi T, Hirokawa Y, Tokura Y. Purpuric adult T-cell leukaemia/lymphoma: expansion of unusual CD4/CD8 double-negative malignant T cells expressing CCR4 but bearing the cytotoxic molecule granzyme B. Br J Dermatol 2005; 152: 350–352. DOI: https://doi.org/10.1111/j.1365-2133.2004.06281.x

Ishida T, Utsunomiya A, Iida S, Inagaki H, Takatsuka Y, Kusumoto S, et al. Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res 2003; 9: 3625–3634.

Tamaki T, Karube K, Sakihama S, Tsuruta Y, Awazawa R, Hayashi M, et al. A comprehensive study of the immunophenotype and its clinicopathologic significance in adult T-cell leukemia/lymphoma. Mod Pathol 2023; 36: 100169. DOI: https://doi.org/10.1016/j.modpat.2023.100169

Published

2026-01-20

How to Cite

Watanabe, K., Natsuga, K., Onozawa, M., Kikuchi, T., & Ujiie, H. (2026). Primary Cutaneous Adult T-cell Leukaemia/Lymphoma Presenting as Generalized Purpura. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0119

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