Non-invasive Analysis of Skin in Recessive Dystrophic Epidermolysis Bullosa Using High-Frequency Ultrasound: A First Case Report

Authors

  • Karl Wallblom Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Dermatology, Skåne University Hospital, Lund, Sweden
  • Katja Holmgren Dermatology and Venereology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Dermatology and Venereology, Uppsala University Hospital, Uppsala, Sweden
  • Sigrid Lundgren Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Dermatology, Skåne University Hospital, Lund, Sweden
  • Torborg Hoppe Dermatology and Venereology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Dermatology and Venereology, Uppsala University Hospital, Uppsala, Sweden
  • Enikö Sonkoly Dermatology and Venereology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Dermatology and Venereology, Uppsala University Hospital, Uppsala, Sweden
  • Artur Schmidtchen Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Dermatology, Skåne University Hospital, Lund, Sweden

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0261

Keywords:

epidermolysis bullosa, skin imaging, subepidermal low-echogenic band, mechanobullous diseases

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References

Bardhan A, Bruckner-Tuderman L, Chapple ILC, Fine JD, Harper N, Has C, et al. Epidermolysis bullosa. Nat Rev Dis Primers 2020; 6: 78. DOI: https://doi.org/10.1038/s41572-020-0210-0

Has C, Bauer JW, Bodemer C, Bolling MC, Bruckner-Tuderman L, Diem A, et al. Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility. Br J Dermatol 2020; 183: 614–627. DOI: https://doi.org/10.1111/bjd.18921

Mellerio JE. Infection and colonization in epidermolysis bullosa. Dermatol Clin 2010; 28: 267–269. DOI: https://doi.org/10.1016/j.det.2010.01.004

Vergilio MM, Monteiro E Silva SA, Jales RM, Leonardi GR. Highfrequency ultrasound as a scientific tool for skin imaging analysis. Exp Dermatol 2021; 30: 897–910. DOI: https://doi.org/10.1111/exd.14363

Polańska A, Dańczak-Pazdrowska A, Silny W, Woźniak A, Maksin K, Jenerowicz D, et al. Comparison between highfrequency ultrasonography (Dermascan C, version 3) and histopathology in atopic dermatitis. Skin Res Technol 2013; 19: 432–437. DOI: https://doi.org/10.1111/srt.12064

6. Polańska A, Silny W, Jenerowicz D, Knioła K, Molińska-Glura M, Dańczak-Pazdrowska A. Monitoring of therapy in atopic dermatitis--observations with the use of high-frequency ultrasonography. Skin Res Technol 2015; 21: 35–40. DOI: https://doi.org/10.1111/srt.12153

Pazdrowski J, Dańczak-Pazdrowska A, Polańska A, Kaźmierska J, Barczak W, Szewczyk M, et al. An ultrasonographic monitoring of skin condition in patients receiving radiotherapy for head and neck cancers. Skin Res Technol 2019; 25: 857–861. DOI: https://doi.org/10.1111/srt.12745

Cisoń H, Jankowska-Konsur A, Białynicki-Birula R. The Evaluation of Skin Infiltration in Mycosis Fungoides/Sézary Syndrome Using the High-Frequency Ultrasonography. J Clin Med 2025; 14: 7143. DOI: https://doi.org/10.3390/jcm14207143

Dini V, Janowska A, Faita F, Panduri S, Benincasa BB, Izzetti R, et al. Ultra-high-frequency ultrasound monitoring of plaque psoriasis during ixekizumab treatment. Skin Res Technol 2021; 27: 277–282. DOI: https://doi.org/10.1111/srt.12942

Wang J, Zhu Q, Li F, Xiao M, Liu J. Clinical, dermoscopic, and ultrasonic monitoring of the response to biologic treatment in patients with moderate-to-severe plaque psoriasis. Front Med 2023; 10: 1162873. DOI: https://doi.org/10.3389/fmed.2023.1162873

Cortex Technology. DermaScan C USB Instruction Manual (Z0300123 UK). Aarhus, Denmark: Cortex Technology; 2023.

Phillips J, Reynolds KJ, Gordon SJ. Dermal thickness and echogenicity using DermaScan C high frequency ultrasound: methodology and reliability testing in people with and without primary lymphoedema. Skin Res Technol 2020; 26: 813–823. DOI: https://doi.org/10.1111/srt.12880

Wallblom K, Schmidtchen A, Puthia M. High-frequency Ultrasound Reveals Epidermal-dermal Structural Alterations in an Experimental Model of Epidermolysis Bullosa. Acta Derm Venereol 2026; accepted.

Guide SV, Gonzalez ME, Bağcı IS, Agostini B, Chen H, Feeney G, et al. Trial of beremagene geperpavec (B-VEC) for dystrophic epidermolysis bullosa. N Engl J Med 2022; 387: 2211–2219. DOI: https://doi.org/10.1056/NEJMoa2206663

Tang JY, Marinkovich MP, Wiss K, McCarthy D, Truesdale A, Chiou AS, et al. Prademagene zamikeracel for recessive dystrophic epidermolysis bullosa wounds (VIITAL): a twocentre, randomised, open-label, intrapatient-controlled phase 3 trial. Lancet 2025; 406: 163–173. DOI: https://doi.org/10.1016/S0140-6736(25)00778-0

Published

2026-01-28

How to Cite

Wallblom, K., Holmgren, K., Lundgren, S., Hoppe, T., Sonkoly, E., & Schmidtchen, A. (2026). Non-invasive Analysis of Skin in Recessive Dystrophic Epidermolysis Bullosa Using High-Frequency Ultrasound: A First Case Report. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0261

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