Subcutaneous Panniculitis-like T-cell Lymphoma with Secondary Haemophagocytic Lymphohistiocytosis Arising at Widespread Tattoo Sites: A Case Report

Authors

  • Ryoko Fukuda Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Mariko Ogawa-Momohara Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Soichi Yoshiyama Department of Hematology, Nagoya Ekisaikai Hospital, Nagoya, Japan
  • Tatsunari Satake Department of Diagnostic Pathology, Nagoya Ekisaikai Hospital, Nagoya, Japan
  • Masashi Akiyama Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0036

Keywords:

Subcutaneous panniculitis-like T-cell lymphoma, hemophagocytic lymphohistiocytosis, tattoo, extracutaneous

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References

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Magro CM, Crowson AN, Kovatich AJ, Burns F. Lupus profundus, indeterminate lymphocytic lobular panniculitis and subcutaneous T-cell lymphoma: a spectrum of subcuticular T-cell lymphoid dyscrasia. J Cutan Pathol 2001; 28: 235–247 DOI: https://doi.org/10.1034/j.1600-0560.2001.028005235.x

Lester L, Ewalt M, Warnke R, Kim J. Systemic panniculitis-like T-cell lymphoma with involvement of mesenteric fat and subcutis. J Cutan Pathol 2015; 42: 46–49 DOI: https://doi.org/10.1111/cup.12436

Kumar S, Krenacs L, Medeiros J, Elenitoba-Johnson KS, Greiner TC, Sorbara L, et al. Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes. Hum Pathol 1998; 29: 397–403 DOI: https://doi.org/10.1016/S0046-8177(98)90122-8

Willemze R, Jansen PM, Cerroni L, Berti E, Santucci M, Assaf C, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC cutaneous lymphoma group study of 83 cases. Blood 2008; 111: 838–845 DOI: https://doi.org/10.1182/blood-2007-04-087288

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Ohtsuka M, Miura T, Yamamoto T. Clinical characteristics, differential diagnosis, and treatment outcome of subcutaneous panniculitis-like T-cell lymphoma: a literature review of published Japanese cases. Eur J Dermatol 2017; 27: 34–41 DOI: https://doi.org/10.1684/ejd.2016.2914

Clemmensen SB, Mengel-From J, Kaprio J, Frederiksen H, von Bornemann Hjelmborg J. Tattoo ink exposure is associated with lymphoma and skin cancers - a Danish study of twins. BMC Public Health 2025; 25: 170 DOI: https://doi.org/10.1186/s12889-025-21413-3

Nielsen C, Jerkeman M, Jöud AS. Tattoos as a risk factor for malignant lymphoma: a population-based case-control study. EClinicalMedicine 2024; 72: 102649 DOI: https://doi.org/10.1016/j.eclinm.2024.102649

Jiang M, Zhao L, Zheng J, Zhang J, Chen P, Zhou W. Report of eleven patients of subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic features, 18F-FDG PET/CT findings and outcome. Front Oncol 2021; 11: 650822 DOI: https://doi.org/10.3389/fonc.2021.650822

Zhang Q, Lin Y, Bao Y, Jin Y, Ye X, Tan Y. Analysis of prognostic risk factors and establishment of prognostic scoring system for secondary adult hemophagocytic syndrome. Curr Oncol 2022; 29: 1136–1149 DOI: https://doi.org/10.3390/curroncol29020097

Portilla Maya N, Kempf W, Perez Muñoz N, Rodríguez-Martínez P, Posada R, Fernández-Figueras MT. Histopathologic spectrum of findings associated with tattoos: multicenter study series of 230 cases. Am J Dermatopathol 2021; 43: 543–553 DOI: https://doi.org/10.1097/DAD.0000000000001695

Published

2026-02-03

How to Cite

Fukuda, R., Ogawa-Momohara, M., Yoshiyama, S., Satake, T., & Akiyama, M. (2026). Subcutaneous Panniculitis-like T-cell Lymphoma with Secondary Haemophagocytic Lymphohistiocytosis Arising at Widespread Tattoo Sites: A Case Report. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0036

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