Vedolizumab-induced Bullous Pemphigoid: A Case Report with Serological Evidence and Mechanistic Insights

Authors

  • Xun Feng Department of Dermatology & Venerology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China
  • Jishu Li Department of Dermatology & Venerology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China
  • Xiaohong Li Department of Outpatient, West China Hospital, Sichuan University, Chengdu, China
  • Yan Zhang Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, China
  • Wei Li Department of Dermatology & Venerology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0090

Keywords:

autoimmune bullous disorder, drug-associated bullous pemphigoid, Vedolizumab

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References

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Verheyden M, Murrell D, Bilgic A. 12871 A systematic review of drug-induced pemphigoid. J Am Acad Dermatol 2020; 83: AB113 DOI: https://doi.org/10.1016/j.jaad.2020.06.539

Feagan BG, Rutgeerts P, Sands BE, Hanauer S, Colombel JF, Sandborn WJ, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med 2013; 369: 699–710 DOI: https://doi.org/10.1056/NEJMoa1215734

Magdaleno-Tapial J, Ferrer-Guillén B, Valenzuela-Oñate C, Esteve-Martínez A. Acneiform eruption induced by vedolizumab. Dermatol Online J 2018; 24: 13030/qt0vg996xr. DOI: https://doi.org/10.5070/D32410041733

Sody E, Körber A. Psoriasis Induced by Vedolizumab. Inflamm Bowel Dis 2017; 23: E9–E11 DOI: https://doi.org/10.1097/MIB.0000000000001011

Odom MB, Chen JN, Echavarria JF, Gilson RT. A case of bullous pemphigoid in an ulcerative colitis patient treated with vedolizumab. JAAD Case Rep 2025; 66: 176–179 DOI: https://doi.org/10.1016/j.jdcr.2025.09.033

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Aho S, Uitto J. Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes. Biochem Biophys Res Commun 1998; 243: 694–699. DOI: https://doi.org/10.1006/bbrc.1998.8162

Sedano R, Dhaliwal I, Ramsewak D, Jairath V. Drug-induced lupus associated with vedolizumab in a patient with Crohn’s disease. Inflamm Bowel Dis 2021; 27: e47–e48 DOI: https://doi.org/10.1093/ibd/izaa331

Licata G, Gambardella A, De Rosa A, Calabrese G, Alfano R, Argenziano G. Hidradenitis suppurativa caused by vedolizumab. Dermatitis 2021; 32: e23–e24 DOI: https://doi.org/10.1097/DER.0000000000000610

Choe SI, Bourgeois J, Nidamanuri S, Rubenzik R. Pyoderma gangrenosum in an ulcerative colitis patient on vedolizumab. Cureus 2024; 16: e69219 DOI: https://doi.org/10.7759/cureus.69219

Published

2026-03-02

How to Cite

Feng, X., Li, J., Li, X., Zhang, Y., & Li, W. (2026). Vedolizumab-induced Bullous Pemphigoid: A Case Report with Serological Evidence and Mechanistic Insights. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0090

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