Line-field Confocal Optical Coherence Tomography Detects Subclinical Disease Activity in Atopic Dermatitis during Treatment with Pimecrolimus: An Intrapatient, Controlled Study

Authors

  • Giuseppe Micali Dermatology Clinic, University of Catania, Catania, Italy https://orcid.org/0000-0002-5157-3939
  • Francesco Lacarrubba Dermatology Clinic, University of Catania, Catania, Italy
  • Maria Letizia Musumeci Global Medical Affairs, Viatris, Milan, Italy
  • Raffaella Mantegazza Global Medical Affairs, Viatris, Milan, Italy
  • Anna Elisa Verzì Dermatology Clinic, University of Catania, Catania, Italy

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0399

Keywords:

atopic dermatitis, pimecrolimus, line-field confocal optical coherence tomography

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References

Al B, Holzscheck N, Traidl S, Freimooser S, Roesner LM, Mießner H, et al. Subclinical inflammation precedes atopic dermatitis relapses. J Allergy Clin Immunol 2025; 156: 1234–1246. DOI: https://doi.org/10.1016/j.jaci.2025.03.033

Augustin M, Luger T, Pincelli C, Reich A, Baselga E, Wahn U. A practical algorithm for the treatment of mild-to-moderate atopic dermatitis (AD) in pediatric patients in Europe: expert recommendations. J Dermatolog Treat 2025; 36: 2503281. DOI: https://doi.org/10.1080/09546634.2025.2503281

Verzì AE, Broggi G, Micali G, Sorci F, Caltabiano R, Lacarrubba F. Line-field confocal optical coherence tomography of psoriasis, eczema and lichen planus: a case series with histopathological correlation. J Eur Acad Dermatol Venereol 2022; 36: 1884–1889. DOI: https://doi.org/10.1111/jdv.18293

Donelli C, Rubegni P, Tognetti L, Lacarrubba F, Di Stefani A, Cappilli S, et al. Inflammatory and infectious skin diseases in line-field confocal optical coherence tomography: state of the art. Ital J Dermatol Venereol 2023; 158: 190–196. DOI: https://doi.org/10.23736/S2784-8671.23.07607-7

Suppa M, Palmisano G, Tognetti L, Lenoir C, Cappilli S, Fontaine M, et al. Line-field confocal optical coherence tomography in melanocytic and non-melanocytic skin tumors. Ital J Dermatol Venerol 2023; 158: 180–189. DOI: https://doi.org/10.23736/S2784-8671.23.07639-9

Dryżałowska Z, Blicharz L, Michalczyk A, Koscian J, Maj M, Czuwara J, et al. The usefulness of line-field confocal optical coherence tomography in monitoring epidermal changes in atopic dermatitis in response to treatment: a pilot study. Diagnostics 2024; 14: 1724. DOI: https://doi.org/10.3390/diagnostics14161724

Le Blay H, Raynaud E, Bouayadi S, Rieux E, Rolland G, Saussine A, et al. Epidermal renewal during the treatment of atopic dermatitis lesions: a study coupling line-field confocal optical coherence tomography with artificial intelligence quantifications: LC-OCT reveals new biological markers of AD. Skin Res Technol 2024; 30: e13891. DOI: https://doi.org/10.1111/srt.13891

Published

2026-03-23

How to Cite

Micali, G., Lacarrubba, F., Musumeci, M. L., Mantegazza, R., & Verzì, A. E. (2026). Line-field Confocal Optical Coherence Tomography Detects Subclinical Disease Activity in Atopic Dermatitis during Treatment with Pimecrolimus: An Intrapatient, Controlled Study. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0399

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