Successful Treatment of Pityriasis Rubra Pilaris with Upadacitinib: Report of Two Cases

Authors

  • Yanyu Du Department of Dermatologic Surgery and Dermatologic Oncology, Guangzhou, China, Dermatology Hospital of Southern Medical University, Guangdong Provincal Dermatology Hospital; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China
  • Xurong Liu Department of Dermatologic Surgery and Dermatologic Oncology, Guangzhou, China, Dermatology Hospital of Southern Medical University, Guangdong Provincal Dermatology Hospital
  • Lian Zhang Department of Dermatologic Surgery and Dermatologic Oncology, Guangzhou, China, Dermatology Hospital of Southern Medical University, Guangdong Provincal Dermatology Hospital
  • Jing Zhong Department of Dermatologic Surgery and Dermatologic Oncology, Guangzhou, China, Dermatology Hospital of Southern Medical University, Guangdong Provincal Dermatology Hospital
  • Renliang He Department of Dermatologic Surgery and Dermatologic Oncology, Guangzhou, China, Dermatology Hospital of Southern Medical University, Guangdong Provincal Dermatology Hospital https://orcid.org/0000-0002-6900-9164

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0149

Keywords:

pityriasis rubra pilaris, janus kinase inhibitor, JAK-STAT

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References

Feldmeyer L, Mylonas A, Demaria O, Mennella A, Yawalkar N, Laffitte E, et al. Interleukin 23-helper T cell 17 axis as a treatment target for pityriasis rubra pilaris. JAMA Dermatol 2017; 153: 304–308. DOI: https://doi.org/10.1001/jamadermatol.2016.5384

Boudreaux BW, Pincelli TP, Bhullar PK, Patel MH, Brumfiel CM, Li X, et al. Secukinumab for the treatment of adult-onset pityriasis rubra pilaris: a single-arm clinical trial with transcriptomic analysis. Br J Dermatol 2022; 187: 650–658. DOI: https://doi.org/10.1111/bjd.21708

Haynes D, Strunck JL, Topham CA, Ortega-Loayza AG, Kent G, Cassidy PB, et al. Evaluation of ixekizumab treatment for patients with pityriasis rubra pilaris: a single-arm trial. JAMA Dermatol 2020; 156: 668–675. DOI: https://doi.org/10.1001/jamadermatol.2020.0932

Napolitano M, Abeni D, Didona B. Biologics for pityriasis rubra pilaris treatment: a review of the literature. J Am Acad Dermatol 2018; 79: 353–359. DOI: https://doi.org/10.1016/j.jaad.2018.03.036

Li Y, Chen Z, He M, Tan X, Nie S, Zeng Y, et al. Successful treatment of erythrodermic pityriasis rubra pilaris with upadacitinib. J Eur Acad Dermatol Venereol 2024; 38: e593–e595. DOI: https://doi.org/10.1111/jdv.19762

Xiaoyuan P, Lin S, Xinyu Z, Qianya S, Mei C, Fei W, et al. Successful treatment of generalized pustular psoriasis coexisting with pityriasis rubra pilaris with upadacitinib. Indian J Pediatr 2024; 91: 1296. DOI: https://doi.org/10.1007/s12098-024-05214-x

Song EJ, Al-Saedy MA, Bouché N. Refractory pityriasis rubra pilaris treated with upadacitinib. JAAD Case Rep 2023; 35: 112–114. DOI: https://doi.org/10.1016/j.jdcr.2023.03.004

Zhang X, Wei K, Song H, Chen X, Yang J, Zhao J, et al. Efficacy and safety of small molecule drugs in the treatment of pityriasis rubra pilaris—a systematic review. Front Med 2025; 12: 1544197. DOI: https://doi.org/10.3389/fmed.2025.1544197

Strunck JL, Cutler B, Rajpal B, Kent G, Haynes D, Topham CA, et al. Pityriasis rubra pilaris response to IL-17A inhibition is associated with IL-17C and CCL20 protein levels. J Invest Dermatol 2022; 142: 235–239. DOI: https://doi.org/10.1016/j.jid.2021.06.009

Virtanen A, Spinelli FR, Telliez JB, O’Shea JJ, Silvennoinen O, Gadina M. JAK inhibitor selectivity: new opportunities, better drugs? Nat Rev Rheumatol 2024; 20: 649–665. DOI: https://doi.org/10.1038/s41584-024-01153-1

Published

2026-03-26

How to Cite

Du, Y., Liu, X., Zhang, L., Zhong, J., & He, R. (2026). Successful Treatment of Pityriasis Rubra Pilaris with Upadacitinib: Report of Two Cases. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0149

Issue

Section

Short Communication