Solitary Oral Progression in a Well-controlled Sézary Syndrome

Authors

  • Gaspard Ferrer Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France
  • Olivier Dereure Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France; Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Inserm, University of Montpellier, Montpellier, France https://orcid.org/0000-0001-8736-1922
  • Quentin Samaran Department of Dermatology, Montpellier University Hospital and Montpellier University, Montpellier, France; Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Inserm, University of Montpellier, Montpellier, France; Epidemiology in Dermatology and Evaluation of Therapeutics (EpiDermE) EA7379, University Paris-Est Créteil Val de Marne, Inserm, Créteil, France

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0449

Keywords:

Cutaneous T-Cell Lymphoma, Sézary syndrome, cutaneous T-cell lymphoma, mogamulizumab, pegylated liposomal doxorubicin, mouth diseases, mouth neoplasms

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References

Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood 2019; 133: 1703– 1714. DOI: https://doi.org/10.1182/blood-2018-11-881268

Scarisbrick JJ, Prince HM, Vermeer MH, Quaglino P, Horwitz S, Porcu P, et al. Cutaneous Lymphoma International Consortium study of outcome in advanced stages of mycosis fungoides and Sézary syndrome: effect of specific prognostic markers on survival and development of a prognostic model. J Clin Oncol 2015; 33: 3766–3773. DOI: https://doi.org/10.1200/JCO.2015.61.7142

Rosebush MS, Allen CM, Accurso BT, Baiocchi RA, Cordell KG. Oral mycosis fungoides: a report of three cases and review of the literature. Head Neck Pathol 2019; 13: 492–499. DOI: https://doi.org/10.1007/s12105-018-0923-5

Rodrigues-Fernandes CI, Vargas PA, de Aquino IG, Lopes MA, Santos-Silva AR. Sézary syndrome: report of a rare case with perioral manifestation and review of the literature. Oral Oncol 2022; 134: 106134. DOI: https://doi.org/10.1016/j.oraloncology.2022.106134

Sultan AS, Mostoufi B, Papadimitriou JC, Koka R, Basile J, Younis RH. Large cell transformation of oral mycosis fungoides. Head Neck Pathol 2018; 12: 247–251. DOI: https://doi.org/10.1007/s12105-017-0840-z

Kim YH, Bagot M, Pinter-Brown L, Rook AH, Porcu P, Horwitz SM, et al. Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial. Lancet Oncol 2018; 19: 1192–1204. DOI: https://doi.org/10.1016/S1470-2045(18)30379-6

Tzoumpa S, Ingen-Housz-Oro S, de Masson A, Pham-Ledard A, El Aarbaoui T, Dereure O, et al. Evolution of patients with Sézary syndrome after mogamulizumab discontinuation for any cause except progression: a multicentre retrospective study (Moga-stop Study). Br J Dermatol 2024; 191: 143–144. DOI: https://doi.org/10.1093/bjd/ljae153

Roelens M, de Masson A, Andrillon A, Ram-Wolff C, Biard L, Boisson M, et al. Mogamulizumab induces long-term immune restoration and reshapes tumour heterogeneity in Sézary syndrome. Br J Dermatol 2022; 186: 1010–1025. DOI: https://doi.org/10.1111/bjd.21018

Published

2026-03-26

How to Cite

Ferrer, G., Dereure, O., & Samaran, Q. (2026). Solitary Oral Progression in a Well-controlled Sézary Syndrome. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0449

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Section

Research letter

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