Successful Treatment of Crohn Disease and Concomitant Alopecia Totalis with Upadacitinib: Case Report and Systematic Review of the Literature

Authors

  • Yuki M.F. Andersen Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark https://orcid.org/0000-0001-6131-2815
  • Farzad Seyed-Alinaghi Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
  • Malene F. Kristiansen Department of Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
  • Simon F. Thomsen Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark

DOI:

https://doi.org/10.2340/actadv.v106.adv-2025-0156

Keywords:

alopecia areata, alopecia totalis, autoimmune, comorbidity, hair loss, inflammatory bowel disease, JAK inhibitor, small molecule, upadacitinib

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References

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Strazzulla LC, Wang EHC, Avila L, Lo Sicco K, Brinster N, Christiano AM, et al. Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis. J Am Acad Dermatol 2018; 78: 1–12. DOI: https://doi.org/10.1016/j.jaad.2017.04.1141

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Sandborn WJ, Feagan BG, Loftus EV Jr, Peyrin-Biroulet L, Van Assche G, D’Haens G, et al. Efficacy and safety of upadacitinib in a randomized trial of patients with crohn’s disease. Gastroenterology 2020; 158: 2123–2138. DOI: https://doi.org/10.1053/j.gastro.2020.01.047

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Novielli D, Foti C, Principi M, Mortato E, Romita P, Dell’Aquila P, et al. Upadacitinib in concurrent Crohn’s disease, atopic dermatitis and alopecia areata: A case report. Acad Dermatol Venereol 2024; 38. DOI: https://doi.org/10.1111/jdv.19377

Maghfour J, Olson J, Conic RRZ, Mesinkovska NA. The Association between Alopecia and Inflammatory bowel disease: a systematic review and meta-analysis. Dermatology (Basel) 2021; 237: 658–672. DOI: https://doi.org/10.1159/000512747

Perez SM, Kabashima K, Reich K, Gilliet M, Gilhar A, Paus R. Lessons from TNF-α Inhibitor-Induced alopecia areata: Does TNF-α operate as a hair follicle immune privilege guardian under inflammatory conditions? J Invest Dermatol 2025; 145: 2410–2416. DOI: https://doi.org/10.1016/j.jid.2025.04.024

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Stirrat T, Thakker S, Bejugam D, Goh C, Lipner SR. Upadacitinib for alopecia: current evidence and clinical insights. Skin Appendage Disord 2025; 11: 320–334. DOI: https://doi.org/10.1159/000544868

Ferreira C, King B, Torres T. JAK inhibitors for the treatment of vitiligo: current evidence and emerging therapeutic potential. Drugs (Abingdon Engl) 2025; 85: 1521–1534. DOI: https://doi.org/10.1007/s40265-025-02246-1

Ackerman LS, Schlosser BJ, Zhan T, Prajapati VH, Fretzin S, Takahashi H, et al. Improvements in moderate-to-severe hidradenitis suppurativa with upadacitinib: Results from a phase 2, randomized, placebo-controlled study. J Am Acad Dermatol 2025; 92: 1252–1260. DOI: https://doi.org/10.1016/j.jaad.2024.12.046

Published

2026-04-20

How to Cite

Andersen, Y. M., Seyed-Alinaghi, F., Kristiansen, M. F., & Thomsen, S. F. (2026). Successful Treatment of Crohn Disease and Concomitant Alopecia Totalis with Upadacitinib: Case Report and Systematic Review of the Literature. Acta Dermato-Venereologica, 106, adv–2025. https://doi.org/10.2340/actadv.v106.adv-2025-0156

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