Successful Treatment of Cutaneous Manifestations of Blau Syndrome with UVA-1 Phototherapy in a Paediatric Patient

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DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0428

Keywords:

Blau Syndrome, UVA-1Phototherapy, Pediatrics, Granulomatous Skin Disease, UVA-1

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References

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Zhong Z, Ding J, Su G, Liao W, Gao Y, Zhu Y, et al. Genetic and clinical features of Blau syndrome among Chinese patients with uveitis. Ophthalmology 2022; 129: 821–828. DOI: https://doi.org/10.1016/j.ophtha.2022.03.014

Lassoued Ferjani H, Kharrat L, Ben Nessib D, Kaffel D, Maatallah K, Hamdi W. Management of Blau syndrome: review and proposal of a treatment algorithm. Eur J Pediatr 2024; 183: 1–7. DOI: https://doi.org/10.1007/s00431-023-05204-9

Jensen ME, Harrell K, McBride JD. Case report: methotrexate and hydroxychloroquine in combination for the treatment of NOD2-mutation-associated Blau syndrome. Front Immunol 2023; 14: 1279329. DOI: https://doi.org/10.3389/fimmu.2023.1279329

Schnopp C, Tzaneva S, Mempel M, Schulmeister K, Abeck D, Tanew A. UVA1 phototherapy for disseminated granuloma annulare. Photodermatol Photoimmunol Photomed 2005; 21: 68–71. DOI: https://doi.org/10.1111/j.1600-0781.2005.00145.x

Lima AL, Goetze S, Illing T, Elsner P. Light and laser modalities in the treatment of cutaneous sarcoidosis: a systematic review. Acta Derm Venereol 2018; 98: 481–483. DOI: https://doi.org/10.2340/00015555-2864

Poline J, Fogel O, Pajot C, Miceli‐Richard C, Rybojad M, Galeotti C, et al. Early‐onset granulomatous arthritis, uveitis and skin rash: characterization of skin involvement in Blau syndrome. Acad Dermatol Venereol 2020; 34: 340–348. DOI: https://doi.org/10.1111/jdv.15963

Stoevesandt J, Morbach H, Martin TM, Zierhut M, Girschick H, Hamm H. Sporadic Blau syndrome with onset of widespread granulomatous dermatitis in the newborn period. Pediatr Dermatol 2010; 27: 69–73. DOI: https://doi.org/10.1111/j.1525-1470.2009.01060.x

Kaufman KP, Becker ML. Distinguishing Blau syndrome from systemic sarcoidosis. Curr Allergy Asthma Rep 2021; 21: 10. DOI: https://doi.org/10.1007/s11882-021-00991-3

Caso F, Costa L, Rigante D, Vitale A, Cimaz R, Lucherini OM, et al. Caveats and truths in genetic, clinical, autoimmune and autoinflammatory issues in Blau syndrome and early onset sarcoidosis. Autoimmun Rev 2014; 13: 1220–1229. DOI: https://doi.org/10.1016/j.autrev.2014.08.010

Matsuda T, Kambe N, Ueki Y, Kanazawa N, Izawa K, Honda Y, et al. Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation. Ann Rheum Dis 2020; 79: 1492–1499. DOI: https://doi.org/10.1136/annrheumdis-2020-217320

Matsuda T, Kambe N, Takimoto-Ito R, Ueki Y, Nakamizo S, Saito MK, et al. Potential benefits of TNF targeting therapy in Blau syndrome, a NOD2-associated systemic autoinflammatory granulomatosis. Front Immunol 2022; 13: 895765. DOI: https://doi.org/10.3389/fimmu.2022.895765

Graefe T, Konrad H, Barta U, Wollina U, Elsner P. Successful ultraviolet A1 treatment of cutaneous sarcoidosis. Br J Dermatol 2001; 145: 354–355. DOI: https://doi.org/10.1046/j.1365-2133.2001.04356.x

Published

2026-05-11

How to Cite

Hacker, V., Ulbrich, A., Marquart, E., Wiesner, T., & Radakovic, S. (2026). Successful Treatment of Cutaneous Manifestations of Blau Syndrome with UVA-1 Phototherapy in a Paediatric Patient. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0428

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