Corticosteroid-resistant Terbinafine-induced Acute Generalized Exanthematous Pustulosis: Therapeutic Challenges and Clinical Infection Overlap

Authors

  • Alessandro Svizzero Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy https://orcid.org/0009-0007-9562-1537
  • Camilla Vassallo Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy https://orcid.org/0000-0002-6689-6714
  • Andrea Michelerio Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy https://orcid.org/0000-0002-2711-6084
  • Arber Selimi Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy
  • Marco Nisi Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy
  • Giacomo Fiandrino Pathology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • Valeria Brazzelli Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy https://orcid.org/0000-0001-5898-6448

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0360

Keywords:

Drug side effects, sensitive skin, psoriasis, psoriasis Agep, atopic dermatitis, Acute Generalized Exanthematous Pustulosis, Drug Eruption, Drug Hypersensitivity, antifungals, terbinafine

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References

Ross CL, Shevchenko A, Mollanazar NK, Hsu S, Motaparthi K. Acute generalized exanthematous pustulosis due to terbinafine. Dermatol Ther 2018; 31: e12617. DOI: https://doi.org/10.1111/dth.12617

Carnio LR, Johnson Shaw ME, Schnur J, Casadesus D. Concurrent terbinafine-induced acute generalised exanthematous pustulosis and hepatitis. BMJ Case Rep 2021; 60: e238930. DOI: https://doi.org/10.1136/bcr-2020-238930

Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP)--a clinical reaction pattern. J Cutan Pathol 2001; 28: 113–119. DOI: https://doi.org/10.1034/j.1600-0560.2001.028003113.x

de Oliveira GV, Maia MLP, Leão FAA, Sad EF, Miotto IZ, Silva MR, et al. What to expect when AGEP is induced by terbinafine? Case report and critical review of the literature. Mycoses 2022; 65: 918–925. DOI: https://doi.org/10.1111/myc.13506

Yanes D, Nguyen E, Imadojemu S, Kroshinsky D. Cyclosporine for treatment of acute generalized exanthematous pustulosis: a retrospective analysis. J Am Acad Dermatol 2020; 83: 263–265. DOI: https://doi.org/10.1016/j.jaad.2020.02.069

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Published

2026-05-18

How to Cite

Svizzero, A., Vassallo, C., Michelerio, A., Selimi, A., Nisi, M., Fiandrino, G., & Brazzelli, V. (2026). Corticosteroid-resistant Terbinafine-induced Acute Generalized Exanthematous Pustulosis: Therapeutic Challenges and Clinical Infection Overlap. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0360

Issue

Vol. 106 (2026)

Section

Short Communication

Categories

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