Polymorphic Skin Rash and Fatigue in a Patient with Diabetes Mellitus: A Quiz

Authors

  • Kaan Yilmaz Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany https://orcid.org/0000-0001-5454-8424
  • Manuel Winkler Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • Blerina Misiraj Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • Karlotta Lammers Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • Cyrill Géraud Department of Dermatology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Section of Clinical and Molecular Dermatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0637

Keywords:

glucagonoma, necrolytic migratory erythema, paraneoplastic syndromes, neuroendocrine tumors, pancreas

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References

John AM, Schwartz RA. Glucagonoma syndrome: a review and update on treatment. J Eur Acad Dermatol Venereol 2016; 30: 2016–2022. DOI: https://doi.org/10.1111/jdv.13752

Toberer F, Hartschuh W, Wiedemeyer K. Glucagonoma-associated necrolytic migratory erythema: the broad spectrum of the clinical and histopathological findings and clues to the diagnosis. Am J Dermatopathol 2019; 41: e29–e32. DOI: https://doi.org/10.1097/DAD.0000000000001219

Li W, Yang X, Deng Y, Jiang Y, Xu G, Li E, et al. Necrolytic migratory erythema is an important visual cutaneous clue of glucagonoma. Sci Rep 2022; 12: 9053. DOI: https://doi.org/10.1038/s41598-022-12882-2

Mastoraki A, Spyropoulos D, Stamatiadi S, Alexandraki K, Mylonakis A, Despotidis M, et al. Glucagonoma of the pancreas: diagnostic approach and therapeutic algorithm for a rare nosological entity. Ann Gastroenterol 2026; 39: 184–190. DOI: https://doi.org/10.20524/aog.2026.1037

Boujan N, Géraud C. Neuropsychiatric symptoms, skin disease, and weight loss: necrolytic migratory erythema and a glucagonoma. Lancet 2020; 395: 985. DOI: https://doi.org/10.1016/S0140-6736(20)30324-X

Cardoso Filho F de A, Feitosa RGF, Fechine COC, Matos CMM de, Cardoso AL, Cardoso DL. Glucagonoma syndrome associated with necrolytic migratory erythema. Rev Assoc Med Bras 2015; 61: 203–206. DOI: https://doi.org/10.1590/1806-9282.61.03.203

Alexander EK, Robinson M, Staniec M, Dluhy RG. Peripheral amino acid and fatty acid infusion for the treatment of necrolytic migratory erythema in the glucagonoma syndrome. Clin Endocrinol (Oxf) 2002; 57: 827–831. DOI: https://doi.org/10.1046/j.1365-2265.2002.01660.x

He S, Zeng W, Geng S, Jia J. Glucagonoma syndrome with atypical necrolytic migratory erythema. Indian J Dermatol Venereol Leprol 2021; 87: 49–53. DOI: https://doi.org/10.4103/ijdvl.IJDVL_588_18

Perrier M, Brugel M, Gérard L, Goichot B, Lièvre A, Lepage C, et al. Characteristics and treatment options of glucagonomas: a national study from the French Group of Endocrine Tumors and ENDOCAN-RENATEN network. Eur J Endocrinol 2023; 189: 575–583. DOI: https://doi.org/10.1093/ejendo/lvad157

Published

2026-05-27

How to Cite

Yilmaz, K., Winkler, M., Misiraj, B., Lammers, K., & Géraud, C. (2026). Polymorphic Skin Rash and Fatigue in a Patient with Diabetes Mellitus: A Quiz. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0637