Application of IL-17A Inhibitors in Psoriasis Complicated by Multiple Infections – Successful Treatment and Insights from a Case of Psoriasis with HIV and Neurosyphilis

Authors

  • Ting-Ting Mao Department of Dermatology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China
  • Fang-Fang Yu Department of Infectious Diseases and Immunology, Tianjin Second People’s Hospital, Tianjin, 300192, China
  • Ping Ma Department of Infectious Diseases and Immunology, Tianjin Second People’s Hospital, Tianjin, 300192, China https://orcid.org/0000-0003-4120-2306
  • Man-Li Qi Department of Dermatology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China https://orcid.org/0009-0004-1898-0868

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0392

Keywords:

Plaque psoriasis, Neurosyphilis, HIV, IL-17A inhibitor

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References

Sanguinetti J, Suar L, Eimer L, Busso C. Successful treatment with risankizumab in a patient with psoriasis and HIV. Medicina 2022; 82: 605–608.

Morar N, Willis-Owen SA, Maurer T, Bunker CB. HIV-associated psoriasis: pathogenesis, clinical features, and management. Lancet Infect Dis 2010; 10: 470–478. DOI: https://doi.org/10.1016/S1473-3099(10)70101-8

Lambert JLW, Segaert S, Ghislain PD, Hillary T, Nikkels A, Willaert F, et al. Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2). J Eur Acad Dermatol Venereol 2020; 34: 1914–1923. DOI: https://doi.org/10.1111/jdv.16683

Smith CH, Jabbar-Lopez ZK, Yiu ZZ, Bale T, Burden AD, Coates LC, et al. British Association of Dermatologists guidelines for biologic therapy for psoriasis 2017. Br J Dermatol 2017; 177: 628–636. DOI: https://doi.org/10.1111/bjd.15665

Menter A, Strober BE, Kaplan DH, Kivelevitch D, Prater EF, Stoff B, et al. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics. J Am Acad Dermatol 2019; 80: 1029–1072. DOI: https://doi.org/10.1016/j.jaad.2018.11.057

Xu J, Gill K, Flora A, Kozera E, Frew JW. The impact of psoriasis biologic therapy on HIV viral load and CD4+ cell counts in HIV-positive individuals: a real-world cohort study. J Eur Acad Dermatol Venereol 2023; 37: 1659–1663. DOI: https://doi.org/10.1111/jdv.19020

Rob F, Rozsypal H. Successful treatment of psoriasis with risankizumab in an HIV positive patient with sexually transmitted infection comorbidities. Dermatol Ther 2022; 35: e15277. DOI: https://doi.org/10.1111/dth.15277

Gao JY, Hu HX, Xiao Y, Xia DM, Jiang L. Li W.Clinical analysis of eight cases of psoriasis complicated with HIV infection treated with biologics. Zhongguo Mafeng Pifubing Zazhi 2025; 41: 559–563.

Maione V, Rovaris S, Romanó C, Bighetti S, Arisi M, Carrera CG, et al. Exploring the impact of guselkumab and risankizumab on psoriasis in HIV-positive patients: insights from four Italian centers. Australas J Dermatol 2025; 66: 215–219. DOI: https://doi.org/10.1111/ajd.14467

Jing XL, Meng ZY, Zhu Y. A case of severe plaque psoriasis complicated with HIV infection treated with secukinumab. Pifuxingbing Zhenliaoxue Zazhi 2025; 32: 285–288.

Published

2026-07-06

How to Cite

Mao, T.-T., Yu, F.-F., Ma, P., & Qi, M.-L. (2026). Application of IL-17A Inhibitors in Psoriasis Complicated by Multiple Infections – Successful Treatment and Insights from a Case of Psoriasis with HIV and Neurosyphilis. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0392

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Short Communication

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