Combination Therapy with Upadacitinib and Acitretin in Recalcitrant Darier Disease: A Case Report

Authors

  • Man Yu Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
  • Xin Peng Institute of TCM Clinical-Basis Research, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China
  • Fanlin Meng Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China https://orcid.org/0009-0004-0524-5821

DOI:

https://doi.org/10.2340/actadv.v106.adv-2026-0662

Keywords:

upadacitinib, JAK inhibitor, refractory, combination therapy, acitretin, Darier’s disease

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References

Stefani C, de Gemmis P, Cattelan P, Tibaudo L, Stagni C, De Sensi E, et al. Expanding the spectrum of Darier Disease variants: 13 novel ATP2A2 genetic variations discovered in an Italian retrospective analysis. Gene 2026; 990: 150071. DOI: https://doi.org/10.1016/j.gene.2026.150071

Zhou MH, Stirrat TP, Edminister JR, Elston DM, Jorizzo J, Motaparthi K, et al. Acantholytic disorders: Update on pathophysiology, diagnosis, and management. J Am Acad Dermatol 2026; 95: 138–147. DOI: https://doi.org/10.1016/j.jaad.2026.02.074

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Beyens A, Speeckaert R. Transient responses to biologic therapy in Darier disease: consider the role of dysbiosis-driven inflammation. J Eur Acad Dermatol Venereol 2026; 40: 351–352. DOI: https://doi.org/10.1111/jdv.70283

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Busto Leis JM, Negre GS, Mayor Ibarguren AP, Pinto PH. Response of Darier disease following treatment with baricitinib. JAMA Dermatol 2022; 158: 699–701. DOI: https://doi.org/10.1001/jamadermatol.2022.1021

Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O’Shea JJ. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat Rev Drug Discov 2017; 16: 843–862. DOI: https://doi.org/10.1038/nrd.2017.201

Parmentier JM, Voss J, Graff C, Schwartz A, Argiriadi M, Friedman M, et al. In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494). BMC Rheumatol 2018; 2: 23. DOI: https://doi.org/10.1186/s41927-018-0031-x

Sun Z, Bao L. A case of Darier disease with p.N767S mutation in ATP2A2 successfully treated with upadacitinib. Am J Dermatopathol 2026; 48: 410–411. DOI: https://doi.org/10.1097/DAD.0000000000003242

Published

2026-08-04

How to Cite

Yu, M., Peng, X., & Meng, F. (2026). Combination Therapy with Upadacitinib and Acitretin in Recalcitrant Darier Disease: A Case Report. Acta Dermato-Venereologica, 106, adv–2026. https://doi.org/10.2340/actadv.v106.adv-2026-0662

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Short Communication

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